摘要
目的：研究Annexin A7蛋白表达与鼻咽癌CT表现的关系。方法：经病理证实鼻咽癌58例，全部病例做鼻咽轴位平扫，部分病例同时做冠状位扫描及增强扫描。应用免疫组化SP法检测58例鼻咽癌患者、20例淋巴结转移性鼻咽癌和24例慢性鼻咽炎患者中的Annexin A7蛋白的表达。结果：鼻咽癌患者中Annexin A7阳性率为87.9%（51/58）；淋巴结转移鼻咽癌中阳性率分别为95.0%（19/20）；对照组鼻咽上皮中阳性率为41.7%（10/24）；Annexin A7表达在转移癌中高于鼻咽癌，鼻咽癌中高于对照组，差异有显著性意义（P＜0.05）；Annexin A7表达与组织分化程度、局部转移、淋巴结转移、远处转移和临床分期有关（P＜0.05），而与年龄、性别无关；Annexin A7表达与CT征象中的侵及后鼻孔、侵及口咽部、颅底骨质破坏及颈部淋巴结转移相关（P＜0.05）。结论：Annexin A7蛋白表达与鼻咽癌分化程度、浸润深度、颅底侵犯有一定相关性，可作为评价鼻咽癌CT表现恶性度及预后的指标。
Abstract
Objective: To study the relationship between the expression of Annexin A7 and CT of nasopharyngeal carcinoma(NPC). Methods: Fifty-eight cases of NPC, 20 cases of lymph node metastatic NPC(LMNPC) and 24 cases of chronic rhinitis(CR) were all performed immunochemistry to detect the expression of Annexin A7. All patients of NPC had axial CT scan and some of the cases had coronal CT scan and contrast enhancement. Results: The positive ratio of Annexin A7 was 87.9%(51/58), 95.0%(19/20) and 41.7%(10/24) in NPC, LMNPC and CR, respectively. The expression of Annexin A7 were higher in LMNPC than NPC, in NPC than CR(P＜0.05). There was correlation of expression of Annexin A7 to differentiation, region of metastasis, lymph node metastasis, distant metastasis and clinical stage(P＜0.05), but no correlation to age and gender. There were correlation among the expression of Annexin A7 to invasion of posterior nares, pharynx oralis and bone destruction of base of skull, cervical lymph node metastasis showed in CT(P＜0.05). Conclusion: There was relationship of the expression of Annexin A7 to differentiation, invasive depth and destruction of base of skull of NPC. And serve as the index of malignancy degree of CT and prognosis of NPC.
关键词
鼻咽肿瘤 /
体层摄影术 /
螺旋计算机 /
膜联蛋白A7
Key words
Nasopharyngeal neoplasms /
Tomography /
spiral computed /
Annexin A7
杨民正;梁庆模.
鼻咽癌CT表现与Annexin A7蛋白表达关系的研究[J]. 中国临床医学影像杂志. 2011, 22(1): 6-9
YANG Min-zheng;LIANG Qing-mo.
Study the relationship between the expression of Annexin A7 and CT ofnasopharyngeal carcinoma[J]. Journal of China Clinic Medical Imaging. 2011, 22(1): 6-9
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