摘要
目的：评价甲状腺乳头状癌术后18F-FDG符合线路显像与131I-SPECT/CT对转移灶的诊断价值。方法：经过甲状腺手术及131I成功清除甲状腺残留组织的56例甲状腺乳头状癌患者，在第2次131I治疗前1周内行18F-FDG符合线路显像，并在给予剂量3.7~7.4GBq 131I后第3天行131I-SPECT/CT，对比分析两种显像结果，并统计分析影响18F-FDG符合线路显像探测效率的因素。结果：131I-SPECT/CT诊断甲状腺乳头状癌术后转移患者的灵敏度、特异性、准确性、阳性预测值、阴性预测值分别为84.21%（32/38），94.44%（17/18），87.5%（49/56），96.97%（32/33），73.91%（17/23）。131I-SPECT/CT诊断甲状腺乳头状癌术后转移患者的灵敏度、准确性、阴性预测值高于18F-FDG符合线路显像（χ2=16.114，14.175，6.285，P均<0.05）。18F-FDG符合线路显像阳性组与阴性组的转移病灶大小分别为（1.83±0.30）cm、（1.29±0.26）cm，差异有统计学意义（P<0.001）。结论：131I-SPECT/CT诊断甲状腺乳头状癌术后转移患者的灵敏度、准确性、阴性预测值高于18F-FDG符合线路显像；18F-FDG符合线路显像是131I-SPECT/CT在甲状腺乳头状癌转移诊断中的重要补充，其探测效率与转移灶大小有关。
Abstract
Objective: The aim of this study was to evaluate the value of 18F-FDG dual head coincidence imaging and 131I-SPECT/CT in the diagnosis of patients with metastatic papillary thyroid carcinoma(PTC). Methods: Fifty-six patients who had thyroidectomy and radioiodine ablation of residual normal thyroid tissue were included. They all had 18F-FDG dual head coincidence imaging and 3 days after giving 3.7~7.4GBq 131I 131I-SPECT/CT were performed. We had comparative analysis of the two imaging results and the variable parameters between the 18F-FDG dual head coincidence imaging positive group and 18F-FDG dual head coincidence imaging negative group. Results: The sensitivity, specificity, accuracy, positive predictive value and negative predictive value were 84.21%(32/38), 94.44%(17/18), 87.5%(49/56), 96.97%(32/33), 73.91%(17/23). The difference was significant between 131I-SPECT/CT and 18F-FDG dual head coincidence imaging in sensitivity, accuracy, negative predictive value(χ2=16.114, 14.175, 6.285, all P<0.05）. Metastatic size of 18F-FDG dual head coincidence imaging positive group and negative group were (1.83±0.30)cm, (1.29±0.26)cm, respectively, the difference between them was statistically significant(P<0.001). Conclusion: 131I-SPECT/CT was likely to disclose more metastasis than 18F-FDG dual head coincidence imaging in patients with PTC. 18F-FDG dual head coincidence imaging is an important supplement of 131I-SPECT/CT in detecting metastatic PTC, the metastatic size affected the sensitivity of 18F-FDG dual head coincidence imaging.
关键词
甲状腺肿瘤 /
癌 /
乳头状 /
肿瘤转移 /
体层摄影术 /
发射型计算机 /
单光子 /
氟脱氧葡萄糖F18
Key words
Thyroid neoplasms /
Carcinoma /
papillary /
Neoplasm metastasis /
Tomography /
emission-computed /
single-photon /
Fluorodeoxyglucose F18
孙云钢;冯会娟;刘金华;胡 瑞;欧阳伟.
18F-FDG符合线路显像与131I-SPECT/CT探测甲状腺乳头状癌术后转移的价值[J]. 中国临床医学影像杂志. 2011, 22(11): 766-769
SUN Yun-gang;FENG Hui-juan;LIU Jin-hua;HU Rui;OUYANG Wei.
Clinical value of 18F-FDG dual head coincidence imaging and 131I-SPECT/CT inthe diagnosis of patients with metastatic after resection of papillary thyroid carcinoma[J]. Journal of China Clinic Medical Imaging. 2011, 22(11): 766-769
中图分类号：
Ｒ736.1
Ｒ730.261
R817.4
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