摘要
目的：探讨心肌超声造影（Myocardial contrast echocardiography, MCE）在检测冠心病早期冠脉微循环内皮损伤中的应用价值。资料与方法：选择冠状动脉造影（Coronary angiography, CAG）检查结果正常的患者20例为冠心病高危人群组（第2组），另选年龄匹配的健康志愿者20例作对照组（第1组）行“声诺维”心肌造影。造影后进行4次闪烁成像，分析两组闪烁显像后心肌血流再灌注充盈曲线，获得再充盈峰值强度（PI）、达峰值强度时间（TP）以及心肌内微泡持续显影时间（T）并作定量分析。结果：第2组4次flash后的峰值强度均低于对照组（P<0.05），达峰值强度时间（TP）以及心肌内微泡持续显影时间均明显大于对照组（P<0.05）。结论：MCE通过定量评价心肌微循环灌注可达到检测冠状动脉微循环内皮功能损伤的目的。
Abstract
Objective: To evaluate myocardial contrast echocardiography for the coronary microvascular endothelial dysfunction in patients without showing coronary obstruction by angiography. Methods: Twenty subjects with angiographically normal coronary arteries were involved in group 2. Twenty healthy volunteers without risk factors for coronary artery disease were control group 1. Real-time myocardial contrast echocardiography(MCE) were performed and flash imaging were applied to evaluate myocardial microcirculation perfusion. The peak video intensity(PI), the time to peak concentration(TP) and the duration time(T) were recorded and analyzed in two groups. Results: The PI of group 2 were lower than that in group 1(P<0.05). The TP and the T of group 2 were longer than those in group 1(P<0.05). Conclusions: Coronary microvascular endothelial dysfunction could be detected early in groups with risk factors for coronary artery disease by MCE.
关键词
冠状动脉疾病 /
微循环 /
冠状血管造影术
Key words
Coronary disease /
Microcirculation /
Coronary angiography
李 馨;陈 宇;贺 声;张云山;何疆春.
心肌造影检测冠状动脉微循环内皮损伤的初步应用研究[J]. 中国临床医学影像杂志. 2011, 22(11): 783-785
LI Xin;CHEN Yu;HE Sheng;ZHANG Yun-shan;HE Jiang-chun.
A preliminary study of myocardial contrast echocardiography for coronary microvascular endothelial dysfunction inpatients with angiographical normal coronary arteries[J]. Journal of China Clinic Medical Imaging. 2011, 22(11): 783-785
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