摘要
目的：探讨血清TNF-α水平及高敏C反应蛋白与颈动脉粥样硬化程度之间的关系。资料与方法：选取颈动脉超声检查确诊的颈动脉粥样硬化患者62例，其中男41例，女21例，年龄52~75岁，平均（65.9±10.2）岁；同期选取无高血压、糖尿病、冠心病或脑血管疾病且颈动脉超声检查正常者25例，男15例，女10例，年龄52~76岁，平均（64.6±8.2）岁。采用ELISA法检测血清TNF-α水平、高敏C反应蛋白，并同健康人比较。对血清TNF-α水平、高敏C反应蛋白与颈动脉粥样硬化程度进行相关性分析。结果：颈动脉粥样硬化超声检查示内膜回声增强变厚，表面粗糙，连续性差，有中断现象。可见形态不一、大小不等的粥样斑块。颈动脉粥样硬化患者血清TNF-α水平为（51.4±6.6）μg/L，显著高于健康人（8.8±1.2）μg/L，P<0.01；高敏C反应蛋白为（8.8±0.56）mmol/L，高于健康人（8.3±0.43）mmol/L，P<0.01，且与颈动脉粥样硬化严重程度分级呈正相关（P<0.01）。结论：颈动脉粥样硬化患者血清TNF-α水平显著升高，高敏C反应蛋白水平升高且与病变严重程度呈正相关。
Abstract
Objective: To study the relationship between serum level of TNF-α, hsCRP and ultrasonic imaging of carotid atherosclerosis. Materials and Methods: The patients with final diagnosis of carotid atherosclerosis as well as healthy individuals were selected and their serum level of TNF-α, hsCRP detected. Statistic methods were used in the interrelationship analysis of the serum level of TNF-α, hsCRP and degree of carotid atherosclerosis. Results: Totally 62 patients with carotid atherosclerosis and 25 healthy individuals were enrolled. The carotid atherosclerosis with ultrasonic image of intimae echo enhancement, rough surface, worse continuity and different shape as well as inequality of size of atherosclerotic plaque were analysed. The serum level of TNF-α in patients with carotid atherosclerosis was (51.4±6.6)μg/L, and was (8.8±1.2)μg/L in healthy individuals, which had significant difference(P<0.01). The serum level of hsCRP in patients with carotid atherosclerosis was (8.8±0.56)mmol/L, and (8.3±0.43)mmol/L in healthy individuals, which had significant difference(P<0.01). It had positive correlation with degree of carotid atherosclerosis(P<0.01). Conclusion: The serum level of TNF-α, hsCRP was significantly higher than those of the healthy individuals, and has positive relation with degree of carotid atherosclerosis.
关键词
颈动脉疾病 /
动脉硬化 /
肿瘤坏死因子α /
C反应蛋白 /
超声检查
Key words
Carotid artery diseases /
Arteriosclerosis /
Tumor necrosis factor-alpha /
C-reactive protein /
Ultrasonography
张 涛;雷新军.
TNF-α、高敏C反应蛋白与颈动脉粥样硬化超声影像的相关性[J]. 中国临床医学影像杂志. 2011, 22(12): 849-851
ZHANG Tao;LEI Xin-jun.
Relationship between TNF-α, hsCRP and ultrasonic imaging of carotid atherosclerosis[J]. Journal of China Clinic Medical Imaging. 2011, 22(12): 849-851
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