摘要
目的：评价三维超声测量先天性膈疝（Congenital diaphragmatic hernia, CDH）胎儿肺容积的准确性，并初步探讨CDH胎儿肺容积改变规律。方法：对10例拟引产的CDH胎儿于引产前1~3d应用三维超声体积自动测量技术（Virtual organ computer-aided analysis, VOCAL）测得其肺容积值，引产后6h内对胎儿进行病检，用水置换法得到其实际容积。同时测量150例正常对照组胎儿肺容积，并与CDH胎儿进行统计学比较。结果：①三维超声测量CDH胎儿肺容积与病检结果间有较好的相关性，相关系数（r）为0.79，偏倚及95%一致性界限分别为0.68cm3及（－4.59~3.24）cm3；②CDH胎儿肺容积较同孕周对照组明显减小。结论：先天性膈疝时胎儿肺脏受压体积明显缩小；三维超声测量CDH胎儿肺容积的准确性较好，可能成为评估其肺发育不良程度的重要方法。
Abstract
Objective: To evaluate the accuracy of 3D ultrasound in estimating lung volume of fetuses with congenital diaphragmatic hernia(CDH), and to determine their volume change by comparing with the normal fetuses. Methods: Fetal lung volumes were measured during 3D ultrasound examination using VOCAL technique in 10 cases with CDH, 1~3 days before termination. Postmortem autopsy was conducted within 6 hours after labor and the lung volume was achieved by water displacement. Using VOCAL technique, lung volumes were also measured in controls and compared with those in CDHs. Results: ①The correlation between measured volume by 3D ultrasound and postmortem examination was good, with correlation coefficient 0.79 in CDH fetuses. The mean bias, 95% limits of agreement were, －0.68cm3 and(－4.59~3.24)cm3, respectively. ②In fetuses with CDH, lung volumes were substantially lower than in normal fetuses. Conclusion: The lung volumes were significantly reduced in CDH fetuses, due to pulmonary compression. Prenatal 3D ultrasound can estimate accurately fetal lung volumes in CDHs, which may become a potential predictor for the degree of pulmonary hypoplasia.
关键词
疝 /
横膈 /
胎儿 /
超声检查 /
产前
Key words
Hernia /
diaphragmatic /
Fetus /
Ultrasonography /
prenatal
张 波;杨太珠.
三维超声在膈疝胎儿肺容积测量中的应用[J]. 中国临床医学影像杂志. 2011, 22(3): 162-164
ZHANG Bo;YANG Tai-zhu.
3D sonographic measurement of lung volume in fetuses with congenital diaphragmatic hernia[J]. Journal of China Clinic Medical Imaging. 2011, 22(3): 162-164
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