摘要
目的：探讨双源CT灌注参数BV、BF、Patlak P对胃癌生物学行为的评估价值。方法：使用双源CT对98例胃癌病人行灌注扫描，获得BF、BV、Patlak P值并以其对胃癌的生物学行为进行评估，以确定该灌注参数的评估价值。结果：双源CT灌注参数BF对无远隔转移组的诊断灵敏度为72.13%，特异度为64.52%，阳性预测值为81.67%，阴性预测值为52.63%，正确率为70.41%。BV对无远隔转移组的诊断灵敏度为68.66%，特异度为51.61%，阳性预测值为75.41%，阴性预测值为43.24%，正确率为63.27%。BV对癌组织局限于浆膜内的诊断灵敏度为60.00%，特异度为69.57%，阳性预测值为86.54%，阴性预测值为34.78%，正确率为62.24%。Patlak P值对癌组织局限于胃壁肌层内的诊断灵敏度为61.54%，特异度为75.86%，阳性预测值为69.57%，阴性预测值为68.75%，正确率为69.09%。Patlak P对癌组织突破浆膜的诊断诊断灵敏度为14.29%，特异度为69.23%，阳性预测值为60%，阴性预测值为20%，正确率为27.27%。结论：双源CT灌注参数BF、BV、Patlak P能够对胃癌的生物学行为进行评估，但仍有一定的局限性。
Abstract
Objective: To investigate the value of dual source CT perfusion imaging parameters, including blood volume(BV), blood flow(BF), and Patlak P value in evaluating the biological behavior of gastric carcinoma. Methods: Dual source CT perfusion imaging was performed in 98 patients of gastric carcinoma. The BV, BF, Patlak P value were obtained to study the relationship between the parameters of perfusion and the biological behavior in gastric cancer, and estimate the value of parameters. Results: The BF could predict gastric carcinoma had no distant metastasis with a sensitivity of 72.13%, a specificity of 64.52%, a positive predictive value of 81.67%, a negative predictive value of 52.63%, and an accuracy of 70.41%. The BV could predict the gastric carcinoma had no distant metastasis with a sensitivity of 68.66%, a specificity of 51.61%, a positive predictive value of 75.41%, a negative predictive value of 43.24%, and an accuracy of 63.27%. The BV could predict gastric carcinoma confined within the serous membrane with a sensitivity of 60.00%, a specificity of 69.57%, a positive predictive value of 86.54%, a negative predictive value of 34.78%, and an accuracy of 62.24%. Patlak P value could predict the gastric carcinoma confined within the muscularis with a sensitivity of 61.54%, a specificity of 75.86%, a positive predictive value of 69.57%, a negative predictive value of 68.75%, and an accuracy of 69.09%. Patlak P value also could predict the gastric carcinoma had protrude beyond the serous membrane with a sensitivity of 14.29%, a specificity of 69.23%, a positive predictive value of 60%, a negative predictive value of 20%, and an accuracy of 27.27%. Conclusion: The dual source CT perfusion imaging parameters could assess the biological behavior of gastric carcinoma, but there still has limitations.
关键词
胃肿瘤 /
体层摄影术 /
X线计算机
Key words
Stomach neoplasms /
Tomography /
X-ray computed
李春志;徐荣天;于晓晶;张元元;金 焱.
双源CT灌注参数评估胃癌生物学行为的诊断试验研究[J]. 中国临床医学影像杂志. 2011, 22(6): 406-409
LI Chun-zhi;XU Rong-tian;YU Xiao-jing;ZHANG Yuan-yuan;JIN Yan.
The research of dual source CT perfusion parameter in biological behavior of gastric carcinoma[J]. Journal of China Clinic Medical Imaging. 2011, 22(6): 406-409
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