摘要
目的：探讨周围型肺癌病理、CT表现与血清肿瘤标志物CEA浓度的相关性。方法：回顾性分析48例周围型肺癌病理、CT表现与血清肿瘤标志物CEA资料，对比分析其病理、CT表现与血清肿瘤标志物CEA关系。结果：30例腺癌CEA浓度为（13.23±20.47）ng/ml，11例鳞癌CEA浓度为（3.62±2.48）ng/ml，腺癌与鳞癌血清CEA浓度差异有统计学意义。肺癌的分化程度与血清肿瘤标志物CEA浓度相关系数r值为-0.017。有深分叶征或瘤体直径≥3cm的肺癌，其血清CEA浓度较无深分叶征或瘤体直径＜3cm高。肺癌有无胸膜凹陷征、毛刺征、支气管气相、增强值≥20HU、空洞、空泡征、毛玻璃征、钙化或肺门、纵隔淋巴结肿大与其血清CEA浓度差异无统计学意义。肺癌Ki-67抗原阳性百分率与血清CEA浓度之间有正相关关系（r=0.576）。26例p53表达阳性肺癌CEA浓度（19.37±24.40）ng/ml，22例p53表达阴性肺癌CEA浓度（3.64±2.11）ng/ml，二者血清CEA浓度差异有统计学意义。结论：肺癌的深分叶征、瘤体直径≥3cm、Ki-67抗原及p53蛋白表达与其血清CEA浓度有一定正相关性，肺癌的分化程度与血清CEA浓度之间差异无统计学意义。
Abstract
Objective: To discuss the correlation of pathology, CT features and serum CEA concentration in peripheral lung cancer. Materials and Methods: The pathology, CT features and the serum CEA concentration in 48 cases of peripheral lung cancer, confirmed by operation and pathology, were analyzed. Results: The serum CEA concentration was (13.23±20.47)ng/ml(adenocarcinoma, n=30), (3.62±2.48)ng/ml(squamous carcinoma, n=11). There was no correlation between the serum CEA concentration and the tumor differentiation degree in lung cancer(r=-0.017). The serum CEA concentration were higher in lung cancer with deep lobulation sign or diameter≥3cm. There was no significant difference between lung cancer with pleural indentation sign, spiculation sign, increased CT value≥20HU after enhancement, calcification or enlargement of hilar or mediastinal lymph nodes and serum CEA concentration. There was positive correlation between the percentage of Ki-67 antigen and the serum CEA concentration in lung cancer(r=0.576). The serum CEA concentration was (19.37±24.40)ng/ml(p53 positive group), (3.64±2.11)ng/ml(p53 negative group). Conclusion: There was positive correlation between serum CEA concentration, the percentage of Ki-67 antigen, expression of p53, deep lobulation sign and diameter≥3cm of peripheral lung cancer. There was no significant difference between tumor differentiation degree and serum CEA concentration in peripheral lung cancer.
关键词
肺肿瘤 /
癌胚抗原 /
体层摄影术 /
螺旋计算机
Key words
Lung neoplasms /
Carcinoembryonic antigen /
Tomography /
spiral computed
谭理连;周 洁;李志铭;江金带;李树欣;张婉红.
周围型肺癌病理、CT表现与血清肿瘤标志物CEA关系研究[J]. 中国临床医学影像杂志. 2011, 22(7): 464-467
TAN Li-lian;ZHOU Jie;LI Zhi-ming;JIANG Jin-dai;LI Shu-xin;ZHANG Wan-hong.
Correlation study of CT features, pathology and the serum CEA concentration in peripheral lung cancer[J]. Journal of China Clinic Medical Imaging. 2011, 22(7): 464-467
中图分类号：
Ｒ734.2
R730.43
Ｒ814.42
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