3D-Watsc成像动态观察兔膝骨性关节炎与病理改变的对照研究

陈常胜; 王锡臻; 郭新全; 孙西河; 邓金龙

中国临床医学影像杂志 ›› 2011, Vol. 22 ›› Issue (7) : 475-478.

论著

3D-Watsc成像动态观察兔膝骨性关节炎与病理改变的对照研究

陈常胜，王锡臻，郭新全，孙西河，邓金龙

作者信息 +

Comparative study of dynamic change in 3D-Watsc and pathologic change in rabbit’s osteoarthritis

CHEN Chang-sheng, WANG Xi-zhen, GUO Xin-quan, SUN Xi-he, DENG Jin-long

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文章历史 +

摘要

目的：通过对照分析兔膝骨性关节炎MRI和病理分级，探讨兔膝关节骨关节炎软骨退变影像学特征的病理学基础。材料和方法：健康新西兰大白兔35只，随机分为5组，除对照组外其他动物均采用前交叉韧带切断术建立骨性关节炎模型，在术后2周、4周、6周、8周分别对另外4组进行MRI 3D-Watsc成像检查和病理学观察，组织标本行HE染色观察退变软骨的组织病理变化。结果：正常对照组兔膝关节软骨在3D-Watsc上软骨呈高信号，与周围组织对比良好。随着术后时间延长，MRI和HE显示软骨破坏日趋明显，MRI分级与病理学分级存在较好的一致性（Kappa值=0.80）。各实验组不同MRI分级间的差异有统计学意义（P<0.05）。不同分级间的两两比较发现对照组-2周组，4周组-6周组，6周组-8周组之间差异无统计学意义（P>0.05），其余各组两两比较差异均有统计学意义（P<0.05）。结论：兔膝关节软骨退变的模型随时间延长软骨退变的病理学评分和MRI分级逐渐升高，3D-Watsc序列能在早期显示软骨改变。

Abstract

Objective: To study the imaging feature and pathologic basis of osteoarthritis(OA) of the rabbit by comparing the relationship between MRI grade and pathological grade of OA. Materials and Methods: Thirty-five healthy New Zealand rabbits were divided into five groups randomly, including normal control group, 2-weeks, 4-weeks, 6-weeks and 8-weeks groups respectively after transaction of anterior cruciate ligament to build OA model. MRI and pathological observation were carried out at corresponding time point. HE was performed to observe the histopathologic changes in the degenerative cartilage. Results: The cartilage showed high signal and high contrast on 3D-Watsc sequence. The damage of cartilage became more severe with time. The MRI grades showed good consistency with pathological grades(Kappa=0.80). The MRI grades were different between each group(P<0.05). No significant differences were found between control and 2-weeks group, 4-weeks and 6-weeks groups, 6-weeks and 8-weeks groups by multiple comparison(P>0.05). The differences between the other pairs were significant(P<0.05). Conclusion: The pathological grades and MRI grades of OA increase gradually with postoperative time. MRI 3D-Watsc is able to observe signal features which changes in early stage of OA.

导出引用

陈常胜;王锡臻;郭新全;孙西河;邓金龙. 3D-Watsc成像动态观察兔膝骨性关节炎与病理改变的对照研究[J]. 中国临床医学影像杂志. 2011, 22(7): 475-478

CHEN Chang-sheng;WANG Xi-zhen;GUO Xin-quan;SUN Xi-he;DENG Jin-long. Comparative study of dynamic change in 3D-Watsc and pathologic change in rabbit’s osteoarthritis[J]. Journal of China Clinic Medical Imaging. 2011, 22(7): 475-478

中图分类号： Ｒ684.3 Ｒ445.2