摘要
目的：探讨125I放射性粒子植入治疗非小细胞肺癌（NSCLC）伴肺不张中PET-CT对肿瘤靶区定位的价值。方法：2006年5月~2009年12月随机选择26例晚期NSCLC合并肺不张患者植入前分别行PET-CT检查，将PET-CT及与其对应的CT图像分别输入计划系统（Treatment plan system，TPS）进行放射治疗剂量计算，将所得靶区体积（Gross tumor volume，GTV）及计划粒子数进行比较。然后做CT引导下经皮穿刺125I粒子植入治疗。结果： PET-CT组和CT组肺癌GTV分别为（51.03±16.02）cm3，（58.10±19.11）cm3，两组应植入粒子数分别为43.88±12.30个和49.46±14.74个，PET-CT组GTV较CT组GTV体积减少12.17%，植入粒子数减少11.28%（P<0.001）。结论：应用PET-CT在NSCLC 125I放射性粒子植入治疗术前肿瘤靶区定位方面较CT更加准确。
Abstract
Objective: To explore the location value of PET-CT in 125I seeds permanent braehytherapy treatment for non-small cell lung carcinoma(NSCLC) patients. Methods: From 26 patients with NSCLC underwent whole body PET-CT scans, PET-CT and CT images were input into the treatment plan system(TPS), radiotheapy dose were calculated, compared with gross tumor volume and the numbers of 125I seeds. Results: The gross tumor volume, the mean number of seeds were (51.03±16.02)cm3, 43.88±12.30, in PET-CT group and (58.10±19.11)cm3, 49.46±14.74 respectively, in CT group, gross tumor volume of PET-CT group reduced 12.17%, number of seeds reduced 11.28%(P<0.001). Conclusion: PET-CT is more accurate than CT alone in the assessment of the radiation target volume for NSCLC patients.
关键词
肺肿瘤 /
癌 /
非小细胞肺 /
正电子发射断层显像术 /
体层摄影术 /
螺旋计算机 /
放射疗法
Key words
Lung neoplasms /
Carcinoma /
non-small-cell lung /
Positron-emission tomography /
Tomography /
spiral computed /
Radiotherapy
霍小东;柴树德;郑广均;杨景魁;梁吉祥;魏 巍.
PET-CT在125I放射性粒子植入治疗肺癌中的作用[J]. 中国临床医学影像杂志. 2011, 22(9): 616-618
HUO Xiao-dong;CHAI Shu-de;ZHENG Guang-jun;YANG Jing-kui;LIANG Ji-xiang;WEI Wei.
Function of PET-CT in 125I seeds permanent braehytherapy treatment for lung cancer[J]. Journal of China Clinic Medical Imaging. 2011, 22(9): 616-618
中图分类号：
Ｒ734.2
Ｒ814.42
R817.4
R730.55
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