Perfusion-weighted imaging in hypertensive encephalopathy: animal model study
GAO Bo1, LV Cui2, LIU Feng-li1, YU Guo-hua1, BA Mao-wen1
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1. Department of Radiology, Yantai Yuhuangding Hospital, Yantai Shandong 264000, China; 2. Department of Neurology, Yantai City Yantaishan Hospital, Yantai Shandong 264001, China
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收稿日期
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出版日期
2012-03-02
1900-01-01
2012-10-20
发布日期
2012-10-20
摘要
目的：探讨高血压脑病兔动物模型的磁共振灌注加权成像（PWI）动态变化。材料与方法：选择健康成年新西兰大白兔20只，随机分成对照组和观察组两组，每组10只。对照组（A组）采用双肾单夹型改良法建立慢性高血压模型作为对照，观察组（B组）肌肉注射重酒石酸间羟胺建立急性高血压动物模型。采用GE Signa HD 3.0T磁共振成像设备，在不同时间点行脑PWI扫描，动态对比观察前、中、后不同部位脑组织脑血容量（CBV）、脑血流量（CBF）、平均通过时间（MTT）变化情况。结果：PWI检查显示脑后部血流灌注变化最明显，前部、中部变化较小；病变区CBV、CBF先逐渐上升，在第9 d达到最高峰，晚于平均动脉压（MAP）在第6 d达到最高峰，然后逐渐下降至基本正常水平；MTT的变化不明显。结论：高血压脑病发病过程中rCBF先增加后下降，其高峰晚于MAP高峰。
Abstract
Objective: To investigate the dynamic changes of hypertensive encephalopathy in animal models by perfusion-weighted imaging(PWI). Methods: Twenty adult New Zealand white rabbits were randomly divided into control group(group A) and study group(group B), 10 cases in each group. A modified Gloidblatt 2K1C were used in rabbits to establish chronic hypertension model for control group, and intramuscular injection of Metaraminol Bitartrate to induce acute hypertension in the study group. Routine MRI scanning and PWI of brain were performed in rabbit models on the 3.0T MRI scanner. The values of CBV, CBF and MTT were calculated in selected region of interest(ROI) at workstation, and were compared among anterior, middle and posterior brain regions. Results: The changes of CBF were most marked in posterior brain regions. The CBV, CBF increased after injection of Metaraminol Bitartrate and reached the peak on the ninth day, later than MAP which reached the peak on the sixth day, and then decreased to a basically normal level after drug withdrawal for one week. The change of MTT was not significant. Conclusions: During the course of hypertensive encephalopathy, the level of rCBF first increases and then declines, the peak of which is later than those of MAP.
GAO Bo;LV Cui;LIU Feng-li;YU Guo-hua;BA Mao-wen.
Perfusion-weighted imaging in hypertensive encephalopathy: animal model study[J]. Journal of China Clinic Medical Imaging. 2012, 23(10): 685-687
