摘要
目的：探讨宫颈癌320 CT灌注成像参数及其临床应用价值。方法：对36例临床诊断为宫颈癌患者行子宫颈CT灌注扫描，其中Ⅰ~Ⅱ期宫颈癌组16例，Ⅲ~Ⅳ期宫颈癌组20例，取15例宫颈癌旁正常组织作为对照组。应用Perfusion CT软件包对灌注图像进行后处理，得到时间-密度曲线（Time density curve，TDC），灌注参数包括：血流量（Blood flow，BF）、血容量（Blood volume，BV）及表面通透性（Permeability surface，PS）。结果：Ⅰ~Ⅱ期宫颈癌组和Ⅲ~Ⅳ期宫颈癌组的BF、BV、PS均高于宫旁正常对照组；Ⅲ~Ⅳ期宫颈癌组的BF、BV、PS均高于Ⅰ~Ⅱ期宫颈癌组，差异均有统计学意义（P<0.05）。灌注值随肿瘤病理分期的升高而增加。结论：子宫颈癌320 CT灌注成像作为一种新的影像学方法，反映子宫肿瘤灌注成像参数及其内部灌注状态可靠，对肿瘤的分期及预后评估、评价肿瘤治疗疗效有重要的临床指导意义。
Abstract
Objective: To investigate the parameters obtained with 320 CT perfusion imaging in cervical cancer and the clinical application. Methods: Thirty-six cases of cervical cancer patients were scanned with Aquilion ONE 320 CT, including 16 cases of stage Ⅰ~Ⅱ cervical cancer and 20 cases of stage Ⅲ~Ⅳ cervical cancer. Fifteen cases of parametrial normal tissues were considered as a control group. Time-density curves(TDC), as well as perfusion parameters, including blood flow(BF), blood volume(BV) and permeability surface(PS) were post-processed by perfusion CT software package. Results: BF, BV and PS were higher in the stage Ⅰ~Ⅱ and Ⅲ~Ⅳ cervical cancer groups than those in the parametrial normal control group; BF, BV and PS were higher in the stage Ⅲ~Ⅳ group than those in the Ⅰ~Ⅱ stage cervical cancer group, with statistically significant differences(P<0.05). Perfusion parameters enhanced with the increase of the tumor stage. Conclusions: 320 CT perfusion imaging in cervical cancer provides a new method to reliably demonstrate the parameters of perfusion imaging and internal perfusion, thus, it is clinically significant for tumor staging, prognosis and evaluation of tumor therapy.
关键词
宫颈肿瘤 /
体层摄影术 /
螺旋计算机
Key words
Cervix neoplasms /
Tomography /
spiral computed
钱昊初;郭文力;王思亮;胡天玉;吴 荣.
宫颈癌Aquilion ONE 320 CT灌注成像表现初探[J]. 中国临床医学影像杂志. 2012, 23(12): 853-855
QIAN Hao-chu;GUO Wen-li;WANG Si-liang;HU Tian-yu;WU Rong.
A study of CT perfusion imaging of cervical cancer on Aquilion ONE 320[J]. Journal of China Clinic Medical Imaging. 2012, 23(12): 853-855
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