摘要
目的：应用瞬时波强（WI）技术结合缺氧诱导因子（HIF-1α）及血管内皮生长因子（VEGF）的变化，探讨高海拔低氧环境对急进高原地区的抗震官兵颈动脉弹性功能及相关细胞因子的影响。方法：选取100例急进高原地区7 d的抗震官兵（高原组）和100例平原健康官兵（对照组），应用WI技术检测两组官兵颈动脉包括压力-应变弹性系数（Ep）、硬化参数（β）、动脉顺应性（AC）、脉搏波反射增强（AI）、脉搏波传导速度（PWV-WI）在内的一系列弹性功能指标，同时检测血液中HIF-1α及VEGF的含量。结果：高原组的HIF-1α及VEGF较对照组均表达上调，PWV-WI增高（P<0.05）。两组间Ep、β、AC、AI无明显差异（P>0.05）。结论：高海拔低氧环境中HIF-1α和VEGF的表达上调可能对动脉弹性功能有调节作用，在反映颈动脉弹性功能的众多指标中，PWV-WI是急进高原地区缺氧反应的敏感指标。
Abstract
Objective: To explore the effect of hypoxia on carotid compliance and related cytokines in anti-seismic soldiers acute exposed to high altitude by using wave intensity(WI) technology and detection of changes of hypoxia induced factor(HIF-1α) and vascular endothelial growth factor(VEGF). Methods: One hundred anti-seismic soldiers acutely exposed to plateau within seven days at Yushu(the high altitude group) and one hundred healthy soldiers living on the plains(the control group) were enrolled, pressure-strain elastic modulus(Ep), stiffness parameter(β), arterial compliance(AC), argumentation index(AI) and pulse wave velocity(PWV-WI) were detected using WI technology, meanwhile VEGF and HIF-1α were measured. Results: Compared with the control group, HIF-1α, VEGF and PWV-WI were higher in the high altitude group(P<0.05). The Ep, β, AC, AI had no significant different between the two groups(P>0.05). Conclusions: In a hypoxia environment, increased HIF-1α and VEGF may had a regulating effect on carotid compliance. Carotid artery elasticity-pulse wave velocity is a sensitive variable reflecting acute high altitude hypoxia reaction.
关键词
颈动脉 /
弹性 /
超声检查 /
多普勒 /
彩色
Key words
Carotid arteries /
Elasticity /
Ultrasonography /
Doppler /
color
刘爱玲;姚胜银;沈丽群;曹小勇;周爱香;阴海霞;姜海艳;马丽晶;杨巧玲.
急进高海拔地区的抗震官兵颈动脉弹性功能及相关细胞因子的变化初探[J]. 中国临床医学影像杂志. 2012, 23(4): 236-238
LIU Ai-ling;YAO Sheng-yin;SHEN Li-qun;CAO Xiao-yong;ZHOU Ai-xiang;YIN Hai-xia;JIANG Hai-yan;MA Li-jing;YANG Qiao-ling.
Study on changes of carotid compliance and related cytokines in anti-seismic soldiers on acute exposure to high altitude[J]. Journal of China Clinic Medical Imaging. 2012, 23(4): 236-238
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