摘要
目的：应用瞬时波强（Wave intensity，WI）技术评价绝经期前女性系统性红斑狼疮（Systemic lupus erythematosus，SLE）患者颈动脉血管内皮弹性功能改变，探讨WI技术在早期诊断SLE患者动脉粥样硬化方面的临床应用价值。材料与方法：根据病程将60例女性SLE患者分为SLE 1组（病史<5年）和SLE 2组（病史≥5年），用WI技术依次检查SLE 1组30例、SLE 2组30例和正常对照组30例，采集WI相关参数瞬时加速度波强（W1）、瞬时减速度波强（W2）、瞬时波强负向波面积（NA）、僵硬度（β）、瞬时波强脉搏波传导速度（PWV-WI）、脉搏波传导速度（PWVβ）、压力应变弹性系数（Ep）、顺应性（AC）、增大指数（AI）及内中膜厚度（IMT），并进行分析。结果：与正常对照组比较，SLE 1组、SLE 2组患者W2、β、Ep、PWV-WI、PWVβ值增高，AC值降低，差异有统计学意义（P≤0．01），3组W1、AI、NA值逐渐增高，差异无统计学意义。SLE 2组的W2、PWV-WI、β、Ep、PWVβ均较SLE 1组显著升高，AC显著降低，差异有统计学意义（P≤0．01）。结论：应用WI技术可早期检测SLE患者颈动脉弹性的变化，对临床早期防治心血管并发症的发生具有一定的指导意义。
Abstract
Objective: To observe the clinical value of early diagnosis of atherosclerosis in patients with systemic lupus erythematosus(SLE) using wave intensity technique and to evaluate changes of elasticity of carotid artery in pre-menopausal SLE patients． Materials and Methods: Sixty patients with SLE were divided into two groups according to different clinical courses: SLE group 1(duration<5 years), and SLE group 2(duration≥5 years). A Wave intensity method was used to measure and analyze instantaneous acceleration Wave intensity(W1), instantaneous deceleration Wave intensity(W2), negative area(NA), stiffness constant(β), one-point pulse wave velocity(PWVβ and PWV-WI), pressure strain elastic modulus(Ep), arterial compliance(AC), augmentation index(AI) and intimamedia thickness(IMT) of the right carotid arteries in 60 patients with SLE and in 30 normal control individuals． Results: Compared with the normal group, W2, β, Ep, PWV-WI, PWVβ of SLE group 1 and SLE group 2 were higher than those of the control group, but AC was lower than that of the control, with a statistically significant difference(P≤0．01)． W1, AI, NA values were different in the three groups, but the difference was not statistically significant(P>0．01). W2, PWV-WI, β, Ep, PWVβ significantly increased in SLE group 2 comparing with SLE group 1, but AC decreased, with a statistically significant difference(P≤0．01)． Conclusion: WI technique can detect the early changes of carotid elasticity in systemic lupus erythematosus patients. It may be useful for prevention and treatment of the complicated cardiovascular disease．
关键词
红斑狼疮 /
系统性 /
颈动脉 /
弹性 /
超声检查
Key words
Lupus erythematosus /
systemic /
Carotid arteries /
Elasticity /
Ultrasonography
刘春丽;张连仲;鲁 豫;段少博.
瞬时波强技术早期评价系统性红斑狼疮患者颈动脉弹性功能[J]. 中国临床医学影像杂志. 2012, 23(8): 541-544
LIU Chun-li;ZHANG Lian-zhong;LU Yu;DUAN Shao-bo.
Early evaluation of carotid elasticity function in patients with systemic lupus erythematosus by wave intensity technique[J]. Journal of China Clinic Medical Imaging. 2012, 23(8): 541-544
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