在体肝脏质子3.0T MR波谱谱线后处理的应用研究

徐 莉;黄 燕;刘 波;刘 岘;王荣品

中国临床医学影像杂志 ›› 2012, Vol. 23 ›› Issue (8) : 553-555.

中国临床医学影像杂志 ›› 2012, Vol. 23 ›› Issue (8) : 553-555.
论著

在体肝脏质子3.0T MR波谱谱线后处理的应用研究

  • 徐 莉1,黄 燕1,刘 波1,刘 岘1,王荣品2
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The study of post-processing of hepatic proton MRS in vivo on 3.0T MR scanner

  • XU Li1, HUANG Yan1, LIU Bo1, LIU Xian1, WANG Rong-pin2
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摘要

目的:探讨在体肝脏单体素3.0T 1H-MRS谱线后处理方法。材料和方法:46例受检者,男26例,女20例,年龄19~67岁,中位年龄39岁,包括正常29例、慢性乙型肝炎4例、脂肪肝10例和脂肪肝合并慢性乙型肝炎3例。使用GE Signa Excite HD 3.0T超导型磁共振扫描仪,8通道相控阵线圈。1H-MRS采集使用单体素PRESS序列,参数为TR/TE:1 500 ms/30 ms,NSA:64次,VOI:2 cm×2 cm×2 cm。采用专用波谱后处理软件SAGE 7.3对谱线进行分析。同一谱线采用Spectrum及Probe后处理方法。评价后处理截趾对基线稳定性和SNR的影响及采用配对样本秩和检验。后处理截趾对拟合线宽、峰高及峰下面积的影响采用配对样本t检验。结果:Spectrum方法为要水峰的后处理,显示的代谢物峰较少,主要为4.7 ppm处的水峰与1.3 ppm处的亚甲基峰;Probe方法为不要水峰的后处理,显示代谢物峰个数较多。两种方法均可获得各种化合物峰高、峰下面积及其相互间的比率。5 Hz较1.25 Hz指数函数处理的波谱原始数据所获谱线SNR好,但谱线宽度及峰下面积增加。结论:对脂肪含量进行以水为内参照绝对定量分析可以使用Spectrum方法,而Probe方法有助于含量较少的化合物的显示。相较于1.25 Hz,推荐使用5 Hz的指数函数处理在体肝脏波谱原始数据。

Abstract

Objectives: To investigate the post-processing of hepatic MRS findings in vivo. Materials and Methods: A total of 58 single-voxel proton spectra of the liver were acquired on 3.0T scanner using the eight-channel phased array abdomen coil. Consecutive stacks of breathhold spectra were acquired using the PRESS technique with a short echo time of 30 ms and a repetition time of 1 500 ms. The spectra was processed with the software package “SAGE”. Areas and heights for metabolites resonances were obtained. Results: The method Spectrum of raw MRS data showed more metabolites resonances peaks than the method Probe. The group using the parameter 5 Hz had better SNR than that using the parameter 1.25 Hz. The lipid peak height was wider. Conclusions: The parameters 5 Hz is better in post-prosessing of hepatic proton MRS at 3.0T.

关键词

肝疾病 / 磁共振波谱学

Key words

Liver diseases / Magnetic resonance spectroscopy

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导出引用
徐 莉;黄 燕;刘 波;刘 岘;王荣品. 在体肝脏质子3.0T MR波谱谱线后处理的应用研究[J]. 中国临床医学影像杂志. 2012, 23(8): 553-555
XU Li;HUANG Yan;LIU Bo;LIU Xian;WANG Rong-pin. The study of post-processing of hepatic proton MRS in vivo on 3.0T MR scanner[J]. Journal of China Clinic Medical Imaging. 2012, 23(8): 553-555
中图分类号: R575    R445.2   

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