在体肝脏质子3.0T MR波谱谱线后处理的应用研究

徐莉; 黄燕; 刘波; 刘岘; 王荣品

中国临床医学影像杂志 ›› 2012, Vol. 23 ›› Issue (8) : 553-555.

论著

在体肝脏质子3.0T MR波谱谱线后处理的应用研究

徐莉1，黄燕1，刘波1，刘岘1，王荣品2

作者信息 +

The study of post-processing of hepatic proton MRS in vivo on 3.0T MR scanner

XU Li1, HUANG Yan1, LIU Bo1, LIU Xian1, WANG Rong-pin2

Author information +

文章历史 +

摘要

目的：探讨在体肝脏单体素3.0T 1H-MRS谱线后处理方法。材料和方法：46例受检者，男26例，女20例，年龄19～67岁，中位年龄39岁，包括正常29例、慢性乙型肝炎4例、脂肪肝10例和脂肪肝合并慢性乙型肝炎3例。使用GE Signa Excite HD 3.0T超导型磁共振扫描仪，8通道相控阵线圈。1H-MRS采集使用单体素PRESS序列，参数为TR/TE：1 500 ms/30 ms，NSA：64次，VOI：2 cm×2 cm×2 cm。采用专用波谱后处理软件SAGE 7.3对谱线进行分析。同一谱线采用Spectrum及Probe后处理方法。评价后处理截趾对基线稳定性和SNR的影响及采用配对样本秩和检验。后处理截趾对拟合线宽、峰高及峰下面积的影响采用配对样本t检验。结果：Spectrum方法为要水峰的后处理，显示的代谢物峰较少，主要为4.7 ppm处的水峰与1.3 ppm处的亚甲基峰；Probe方法为不要水峰的后处理，显示代谢物峰个数较多。两种方法均可获得各种化合物峰高、峰下面积及其相互间的比率。5 Hz较1.25 Hz指数函数处理的波谱原始数据所获谱线SNR好，但谱线宽度及峰下面积增加。结论：对脂肪含量进行以水为内参照绝对定量分析可以使用Spectrum方法，而Probe方法有助于含量较少的化合物的显示。相较于1.25 Hz，推荐使用5 Hz的指数函数处理在体肝脏波谱原始数据。

Abstract

Objectives: To investigate the post-processing of hepatic MRS findings in vivo. Materials and Methods: A total of 58 single-voxel proton spectra of the liver were acquired on 3.0T scanner using the eight-channel phased array abdomen coil. Consecutive stacks of breathhold spectra were acquired using the PRESS technique with a short echo time of 30 ms and a repetition time of 1 500 ms. The spectra was processed with the software package “SAGE”. Areas and heights for metabolites resonances were obtained. Results: The method Spectrum of raw MRS data showed more metabolites resonances peaks than the method Probe. The group using the parameter 5 Hz had better SNR than that using the parameter 1.25 Hz. The lipid peak height was wider. Conclusions: The parameters 5 Hz is better in post-prosessing of hepatic proton MRS at 3.0T.

导出引用

徐莉;黄燕;刘波;刘岘;王荣品. 在体肝脏质子3.0T MR波谱谱线后处理的应用研究[J]. 中国临床医学影像杂志. 2012, 23(8): 553-555

XU Li;HUANG Yan;LIU Bo;LIU Xian;WANG Rong-pin. The study of post-processing of hepatic proton MRS in vivo on 3.0T MR scanner[J]. Journal of China Clinic Medical Imaging. 2012, 23(8): 553-555

中图分类号： Ｒ575 Ｒ445.2