摘要
目的：探讨使用磁共振波谱（MRS）分析胶质瘤瘤周代谢物。材料与方法：回顾和分析经临床诊断或经手术病理证实的32例脑胶质瘤MR图像及1H-MRS资料，对瘤体水肿内外带和正常脑组织行1H-MRS分析，比较不同区域代谢物Cho、NAA、Cr的浓度和Cho/Cr、NAA/Cr、NAA/Cho的比值差异性。结果：正常脑组织、瘤周外带和内带的NAA/Cho比值分别为1.67±0.64、1.32±1.13和0.84±0.62，有统计学差异（P<0.05）；正常脑组织、瘤周外带和内带的Cho分别为13.28±3.49，15.66±8.13和16.38±7.77，无统计学差异（P>0.05）；正常脑组织、瘤周外带和内带的NAA分别为20.67±5.52，14.25±5.52和10.48±4.82，有统计学差异（P<0.05）；正常脑组织、瘤周外带和内带的Cr分别为11.82±3.77，10.10±3.49和10.51±5.18，无统计学差异（P>0.05）。结论：1H-MRS分析可以反映脑胶质瘤瘤周的NAA和NAA/Cho比值差异。
Abstract
Objective: To study the value of 1H magnetic resonance spectroscopy(1H-MRS) in the peri-tumor edema region of brain glioma． Materials and Methods: MRI and MRS data of 32 patients confirmed by clinical or histopathologic results were analyzed retrospectively． MRS analysis data was obtained in the medial and lateral zones of peri-tumor regions and normal brain regions. The concentration of Cho, NAA, Cr and the ratio of Cho/Cr, NAA/Cr, NAA/Cho in the lateral and medial edema regions of peri-tumor and normal brain regions were calculated． Results: NAA/Cho ratio of the normal brain regions, lateral and medial edema zones of peri-tumor was 1.67±0.64, 1.32±1.13, 0.84±0.62, respectively, there were significant difference between them(P<0.05)． The Cho concentration of the normal brain regions, lateral and medial edema zones of peri-tumor was 13.28±3.49, 15.66±8.13 and 16.38±7.77, respectively, there was no significant difference between them(P>0．05)． The NAA concentration of the normal brain regions, lateral and medial edema zones of peri-tumor was 20.67±5.52, 14.25±5.52 and 10.48±4.82, respectively, there was significant difference between them(P<0.05)． The Cr concentration of the normal brain regions, lateral and medial edema zones of peri-tumor was 11.82±3.77, 10.10±3.49 and 10.51±5.18, respectively, there was no significant difference between them(P>0.05)． Conclusion: Different metabolic changes of NAA and NAA/Cho in the peri-tumor regions can be detected by using 1H-MRS.
关键词
脑肿瘤 /
神经胶质瘤 /
磁共振波谱学
Key words
Brain neoplasms /
Glioma /
Magnetic resonance imaging
段 阳;杨本强;周丽娟;马红丽;刘文源;周 姝;赖树盛;刘 宇.
脑胶质瘤瘤周的1H-MRS分析[J]. 中国临床医学影像杂志. 2012, 23(9): 609-612
DUAN Yang;YANG Ben-qiang;ZHOU Li-juan;MA Hong-li;LIU Wen-yuan;ZHOU Shu;LAI Shu-sheng;LIU Yu.
1H-magnetic resonance spectroscopy analysis of peri-tumor region in brain glioma[J]. Journal of China Clinic Medical Imaging. 2012, 23(9): 609-612
中图分类号：
Ｒ739.41
R730.264
Ｒ445.2
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