摘要
本文简要介绍磁共振扩散加权成像（MRI-DWI）原理和影响因素，多b值DWI成像临床应用，以及采用传统简单水扩散原理在对DWI临床图像进行解释时存在的一些挑战。然后重点介绍水通道蛋白（Aquaproins，AQPs）理论和研究现状，以及生理和病理情况下表观扩散系数（ADC）与AQP表达之间的关系和研究进展。迄今，还没有通过分子影像技术直接获得ADC与AQP表达之间关系的结果。最后对基于AQP分子成像前景进行介绍，需要从分子生物学、分子医学和分子影像的新观点重新认识MRI水分子成像技术和其潜在的临床应用。
Abstract
This paper briefly introduces the principles and influence factors of diffusion weighted MRI(DW MRI), and multi-b values in clinical application of DWI. The challenges exist in using traditional simple water diffusion to interpret the principle of clinical DW MR imaging were also discussed. The theory of aquaporin and its recent research status, as well as the relationship between apparent diffusion coefficient(ADC) under pathological and physiological condition and water channel protein(aquaproins, AQPs) expression were focused on. Until now, no result was acquired through using molecular imaging technique for direct access of the relationship between ADC and AQP expression. Finally, the new prospect of the water channel protein molecular imaging was introduced. From the aspect of molecular biology, molecular medicine and molecular imaging to renew knowledge and upgrade the point of view in recognizing water diffusion MR imaging and its potential clinical application is urgent and important.
关键词
磁共振成像 /
扩散
Key words
Diffusion magnetic resonance imaging
郭启勇;辛 军;张 新;于 兵;赵周社;李宏利;李 红;王晓明;廖 伟.
MRI水扩散加权成像分子机理研究进展[J]. 中国临床医学影像杂志. 2013, 24(07): 496-500
GUO Qi-yong;XIN Jun;ZHANG Xin;YU Bing;ZHAO Zhou-she;LI Hong-li;LI Hong;WANG Xiao-ming;LIAO Wei.
Progress in the study of molecular mechanism in water diffusion weighted MRI[J]. Journal of China Clinic Medical Imaging. 2013, 24(07): 496-500
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