摘要
目的：应用PET-CT研究18F-FLT、18F-FDG摄取在肿瘤放疗后早期疗效评价中的应用价值。方法：荷Walker 256肿瘤Wistar大鼠放疗前及放疗后24 h、48 h分别行18F-FLT与18F-FDG PET-CT显像，定量测定放疗前后肿瘤18F-FLT与18F-FDG摄取（肿瘤部位ROI内放射性计数与对侧相同部位软组织相同面积ROI内放射性计数比值（T/NT）、每克肿瘤组织摄取放射性百分比（%ID/g））及肿瘤组织Ki-67阳性指数，统计分析放疗前后肿瘤摄取的变化以及与肿瘤细胞增殖活性的相关性。结果：放疗后24 h及48 h大鼠肿瘤部位18F-FLT放射性分布较对照组降低（P<0.001）。与对照组相比，LI-Ki-67在放疗后24 h及48 h均明显降低（P<0.001）。放疗后24 h及48 h的18F-FDG放射性分别较对照组降低不明显（P>0.05，P>0.01）。放疗前后18F-FLT及18F-FDG摄取（T/NT）与%ID/g均呈正相关（r分别0.807和0.813）。结论：Wistar大鼠Walker 256肿瘤放疗后早期，18F-FLT摄取降低，且与肿瘤细胞增殖活性呈正相关，而18F-FDG摄取降低不明显，与肿瘤细胞增殖活性相关不明显。18F-FLT可用于Wistar大鼠Walker 256肿瘤放疗后早期疗效的评价。
Abstract
Objective: To evaluate the 18F-FLT and 18F-FDG uptake as an indicator of early tumor response after radiotherapy. Methods: 18F-FLT and 18F-FDG PET-CT imaging were performed before treatment, 24 h and 48 h after radiotherapy on Wistar rats bearing Walkar 256 tumor. Quantitative data were expressed as percent of injected dose per gram(%ID/g) and tumor to non-tumor radioactivity ratios(T/NT). Correlation between %ID/g and T/NT with proliferation index(Ki-67) were measured. Results: 18F-FLT uptake in tumor decreased early after radiotherapy(P<0.001), LI-Ki-67 decreased early after radiotherapy(P<0.001) compared with controls. 18F-FDG uptake in tumor not decreased significantly 24 h and 48 h after radiotherapy(P>0.05，P>0.01), 18F-FLT uptake was positively correlated with LI-Ki-67(r=0.889). 18F-FDG uptake was not positively correlated with LI-Ki-67(r=0.379). 18F-FLT and 18F-FDG uptakes(T/NT) were positively correlated with %ID/g(r=0.807 and 0.813, respectively). Conclusion: 18F-FLT uptake decreased early after radiotherapy, and the uptake correlated significantly with proliferation of tumor cells early after radiotherapy. 18F-FDG uptake decreased slightly. 18F-FLT is better than 18F-FDG for the assessment of changes of cell proliferation early after radiotherapy.
关键词
肿瘤 /
放射疗法 /
治疗效果 /
氟脱氧葡萄糖F18 /
正电子发射断层显像术
Key words
Neoplasms /
Radiotherapy /
Treatment outcome /
Fluorodeoxyglucose F18 /
Positron-emission tomography
徐微娜;于树鹏;辛 军;郭启勇.
18F-FLT、18F-FDG PET-CT显像评价Wistar大鼠Walker 256肿瘤放疗后早期疗效的研究[J]. 中国临床医学影像杂志. 2013, 24(12): 877-881
XU Wei-na;YU Shu-peng;XIN Jun;GUO Qi-yong.
Early assessment of radiotherapy response of Walker 256 tumor in Wistar rats by 18F-FLT and 18F-FDG PET-CT imaging[J]. Journal of China Clinic Medical Imaging. 2013, 24(12): 877-881
中图分类号：
Ｒ730
Ｒ730.55
Ｒ817.4
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