抑郁患者自我注意的功能性MRI初步探讨

董海波; 马晓洁; 陈传锋; 李亚迪

中国临床医学影像杂志 ›› 2013, Vol. 24 ›› Issue (6) : 381-384.

论著

抑郁患者自我注意的功能性MRI初步探讨

董海波1，马晓洁2，陈传锋2，李亚迪1

作者信息 +

Initial study of functional MRI on self-focused attention in depression patients

DONG Hai-bo1, MA Xiao-jie2, CHEN Chuan-feng2, LI Ya-di1

Author information +

文章历史 +

摘要

目的：研究抑郁患者自我注意的大脑皮层功能变化，探讨自我注意是否与抑郁情绪相关。方法：选取8名抑郁患者和9名健康志愿者进行fMRI。采用BOLD组块设计，受试者接受与自我注意相关的3种任务刺激，原始数据经SPM8脑功能MR软件包处理，获得受试者的脑激活图，并进行对照研究，分析抑郁患者和健康志愿者脑激活空间分布的差异。结果：三种靶刺激条件下，抑郁患者比正常志愿者均存在较多激活脑区。抑郁患者在“我”靶刺激条件下脑区激活显著多于“*”和“他”靶刺激条件。结论：抑郁患者可能存在自我注意偏向，抑郁情绪可能与自我注意相关。

Abstract

Objective: To explore the cerebral activation of depression patients when performing self-focused attention tasks and the correlation between self-focused attention and depression. Methods: Eight depressive patients and nine healthy volunteers underwent fMRI scan using three self-focused attentional patterns stimulus in a block design, SPM8 software was used for image data processing. Comparative brain activation maps between depression patients and healthy volunteers were carried out. Results: The active areas of depressive patients are more extensive than that of healthy volunteers in three target stimulus conditions. For the depressed patients, the active areas in the “I” target stimulus conditions are more extensive than that of “He” and “*” conditions. Conclusion: Depressive patients may have self-focused attentional bias, self-focused attention might be associated with depression.

导出引用

董海波;马晓洁;陈传锋;李亚迪. 抑郁患者自我注意的功能性MRI初步探讨[J]. 中国临床医学影像杂志. 2013, 24(6): 381-384

DONG Hai-bo;MA Xiao-jie;CHEN Chuan-feng;LI Ya-di. Initial study of functional MRI on self-focused attention in depression patients[J]. Journal of China Clinic Medical Imaging. 2013, 24(6): 381-384

中图分类号： Ｒ749.4 Ｒ445.2