摘要
目的：研究脑弥漫性轴索损伤（DAI）的磁共振波谱（MRS）表现，探讨MRS技术在DAI诊断和伤情评估中的价值。材料与方法：选择30例DAI患者及10名健康志愿者（对照组）进行1H-MRS扫描，测定脑组织中N-乙酰天门冬氨酸（NAA）、胆碱（Cho）、肌酸（Cr）等代谢物水平，结合患者格拉斯哥昏迷（GCS）评分及格拉斯哥预后（GOS）评分进行相关性分析。结果：DAI组较正常对照组的NAA峰下降、Cho峰升高；NAA/Cho、NAA/Cr值下降，Cho/Cr值上升。NAA/Cr、NAA/Cho、Cho/Cr值变化与DAI患者GCS、GOS存在相关性。结论：MRS能定量测定DAI患者脑组织代谢状况，对DAI程度的判断及预后评估有重要价值。
Abstract
Objective: To study the imaging features of brain diffuse axonal injury(DAI) by magnetic resonance spectroscopy(MRS), and explore the value of MRS in the diagnosis of DAI and severity assessment. Materials and Methods: Thirty patients with DAI(DAI group) and 10 healthy volunteers(control group) undertook 1H-MRS scanning, to assess the metabolite levels of N-acetyl aspartic acid(NAA), choline(Cho), creatine(Cr), combined with Glasgow coma scale(GCS) and Glasgow outcome scale(GOS) score for correlation analysis. Results: Compared with control group, NAA decreased, Cho increased, NAA/Cho, NAA/Cr value decreased and Cho/Cr value increased in DAI group. The change of NAA/Cr, NAA/Cho, Cho/Cr value showed correlation with GCS and GOS in patients with DAI. Conclusion: MRS can quantitatively measure the brain tissue metabolism of patients with DAI, showing important value for the diagnosis and prognosis evaluation of the severity of DAI.
关键词
弥漫性轴索损伤 /
磁共振波谱学
Key words
Diffuse axonal injury /
Magnetic resonance spectroscopy
漆 强;邹玉林;陶仅德;刘 晓;李志娟;陈真平;李兴付;吴慧琴.
弥漫性轴索损伤的MRS诊断与临床预后的相关研究[J]. 中国临床医学影像杂志. 2014, 25(11): 761-763
QI Qiang;ZOU Yu-lin;TAO Jin-de;LIU Xiao;LI Zhi-juan;CHEN Zhen-ping;LI Xing-fu;WU Hui-qin.
Correlation study of MRS diagnosis of diffuse axonal injury with clinical prognosis[J]. Journal of China Clinic Medical Imaging. 2014, 25(11): 761-763
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