乳腺癌超声造影表现与癌组织中C-erbB-2及nm23表达之间关系探讨

乳腺癌超声造影表现与癌组织中C-erbB-2及nm23表达之间关系探讨

刘健;高云华;安绍宇;高砚春;赵晓波;何丽

中国临床医学影像杂志 ›› 2014, Vol. 25 ›› Issue (11) : 764-767.

中国临床医学影像杂志 ›› 2014, Vol. 25 ›› Issue (11) : 764-767.

论著

乳腺癌超声造影表现与癌组织中C-erbB-2及nm23表达之间关系探讨

刘健1，高云华1，安绍宇2，高砚春2，赵晓波2，何丽2

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Research in the relationship between the contrast-enhanced ultrasound images and expression of C-erbB-2, nm23 in breast cancer

LIU Jian1, GAO Yun-hua1, AN Shao-yu2, GAO Yan-chun2, ZHAO Xiao-bo2, HE Li2

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摘要

目的：探讨乳腺癌超声造影特征与C-erbB-2及nm23的阳性表达之间的关系。方法：回顾性分析乳腺癌患者超声造影资料与术后C-erbB-2及nm23的免疫组化结果，将造影的各个指标及参数与C-erbB-2及nm23的表达之间的关系进行统计分析。结果：①69例乳腺癌病灶中，C-erbB-2的阳性率及nm23的阳性率分别为66.7%（46/69）、27.5%（19/69），在C-erbB-2阳性者中的nm23的阳性表达率为13.0%（6/46），高于C-erbB-2阴性者中nm23的阳性表达率（56.5%，13/23），差异有统计学意义（P=0.029）。②C-erbB-2表达阳性组中，病灶多表现为高增强、不均匀增强或病灶中央出现灌注缺损区、病灶边缘多表现为放射状增强，在时间强度曲线上显示较高的相对上升斜率及相对达峰强度，与C-erbB-2表达阴性组比较，差异有统计学意义（P<0.05）。③在nm23表达阴性的病灶中，病灶多表现为高增强、病灶边缘多表现为放射状增强，其时间强度曲线显示较高的相对上升斜率，与nm23表达阳性组比较，差异有统计学意义（P<0.05）。结论：乳腺癌超声造影的某些特征与C-erbB-2、nm23等分子生物学指标有一定的关系，可以协助临床预测患者预后。

Abstract

Objective: To discuss the relationship between the contrast-enhanced ultrasound(CEUS) images of the breast cancers and the molecular biology markers of C-erbB-2 and nm23. Methods: The imaging data of CEUS in breast cancer, C-erbB-2 and nm23 immunohistochemical results after operation were analysed retrospectively. Correlation between CEUS indexes or parameters and the expression of C-erbB-2 and nm23 were also studied. Results: ①The positive expression rate of C-erbB-2 and nm23 in breast cancer were 66.7%(46/69) and 27.5%(19/69) respectively. The positive expression of nm23 in the group with C-erbB-2 positive expression was 13%, which was higher than that in the group with C-erbB-2 negative expression. ②In the group with C-erbB-2 positive expression, lesions showed high enhancement, heterogeneous enhancement or lesions with perfusion defect area, peripheral radial enhancment, relative rising slope and relative peak intensity showed significant differences in the time intensity curves, compared with the group with C-erbB-2 negative expression(P<0.05). ③In nm23 negative group, the lesion showed high enhancement, peripheral radial enhancement, and the time intensity curve showed higher relative rising slope with statistical significance(P<0.05) compared with the nm23 positive group. Conclusion: Some contrast-enhanced ultrasound features correlated with C-erbB-2 and nm23 expression in breast cancer, which could be useful to predict the prognosis of patients to some extent.

关键词

乳腺肿瘤 / 超声检查 / 多普勒 / 彩色

Key words

Breast neoplasms / Ultrasonography / Doppler / color

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导出引用

刘健;高云华;安绍宇;高砚春;赵晓波;何丽. 乳腺癌超声造影表现与癌组织中C-erbB-2及nm23表达之间关系探讨[J]. 中国临床医学影像杂志. 2014, 25(11): 764-767

LIU Jian;GAO Yun-hua;AN Shao-yu;GAO Yan-chun;ZHAO Xiao-bo;HE Li. Research in the relationship between the contrast-enhanced ultrasound images and expression of C-erbB-2, nm23 in breast cancer[J]. Journal of China Clinic Medical Imaging. 2014, 25(11): 764-767

中图分类号： Ｒ737.9 Ｒ445.1

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