摘要
目的：以高频超声比较糖尿病肾病V期患者肱动脉与腘动脉血管内皮舒张功能的差异性。方法：分别选择健康志愿者（NC组）、2型糖尿病（DM组）和糖尿病肾病V期透析前（DKD-V组）的患者各20例。利用高频彩色多普勒超声测量肱动脉及腘动脉血管基础状态及加压后血管内径和峰值流速，并计算血流介导的扩张值（FMD）。比较肱动脉及腘动脉FMD及峰值流速的差异。结果：肱动脉FMD（%）、腘动脉FMD（%），NC组、DM组、DKD-V组显著性减少（P<0.05）；肱动脉与腘动脉FMD（%）比较，NC组、DM组、DKD-V组显著性减少（P<0.05）；肱动脉与腘动脉FMD差值（%），NC组、DM组、DKD-V组显著性增加（P<0.05）。结论： DKD-V组患者血管内皮舒张功能障碍重于单纯糖尿病患者，且腘动脉血管内皮舒张功能障碍进展速度大于肱动脉。
Abstract
Objective: To study the difference of vascular endothelial function by evaluating flow mediated dilation(FMD) of brachial artery and popliteal artery in diabetic kidney disease(DKD) patients with high frequency ultrasound. Methods: Vascular diameter and velocity in baseline and after reactive hyperaemia of brachial artery and popliteal artery were detected with high frequency ultrasound in 20 healthy volunteers, type 2 diabetic mellitus(T2DM) and patients with DKD-V pre-hemodialysis, FMD were calculated and compared between the 3 groups. Results: Difference of brachial artery FMD and popliteal artery FMD between each two groups were significant(P<0.05). Difference of FMD between brachial artery and popliteal artery in each group were significant(P<0.05). The difference between each two groups of brachial artery and popliteal artery FMD were significant(P<0.05) and increased as disease progress. Conclusion: When T2DM involved kidney, endothelial dysfunction of popliteal artery progress faster than brachial artery.
关键词
糖尿病肾病 /
肱动脉 /
超声检查
Key words
Diabetic neophropathies /
Brachial artery /
Ultrasonography
张月月;徐 岩;李 翔.
糖尿病肾病患者肱动脉与腘动脉血管内皮舒张功能对比性研究[J]. 中国临床医学影像杂志. 2014, 25(2): 109-112
ZHANG Yue-yue;XU Yan;LI Xiang.
Flow mediated dilation of brachial artery and popliteal artery in diabetic kidney disease using high frequency ultrasound: a comparative study[J]. Journal of China Clinic Medical Imaging. 2014, 25(2): 109-112
中图分类号：
Ｒ587.2
Ｒ692
Ｒ445.1
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