帕金森病基于体素的MRI形态学研究

丁洪彬; 田为中; 张继; 陈小云; 夏建国; 赵金丽; 顾红梅

中国临床医学影像杂志 ›› 2014, Vol. 25 ›› Issue (3) : 158-161.

论著

帕金森病基于体素的MRI形态学研究

丁洪彬1，田为中1，张继1，陈小云1, 夏建国1，赵金丽2，顾红梅2

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A voxel-based MRI morphometric study of Parkinson’s disease

DING Hong-bin1, TIAN Wei-zhong1, ZHANG Ji1, CHEN Xiao-yun1, XIA Jian-guo1, ZHAO Jin-li2, GU Hong-mei2

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摘要

目的：用基于体素的形态学分析（VBM）方法,研究帕金森病（PD）患者全脑灰质体积异常区域及分布特征。方法：采集3.0T高场强MR高分辨T1WI，运用VBM方法对25例PD患者及23例健康对照组的大脑灰质图像进行比较，并对两组数据的灰质体积差异采用国际通用的统计参数图表示。结果：PD患者的脑灰质体积较对照组广泛减少，这些区域包括双侧岛叶、海马旁回、杏仁核，右侧颞叶、枕叶、顶叶、额叶，此外还有左额内侧回等区域。结论：VBM方法能较全面、准确、定量地表现PD患者广泛存在的脑灰质体积缺失区域，可以为PD患者的多系统受累的病理机制提供必要的神经影像学依据。

Abstract

Objective: To investigate the abnormal region of gray matter and its’ distribution in Parkinson’s disease(PD) patients using voxel-based morphometry(VBM) method. Method: Twenty-five cases of clinically defined PD patients and 23 cases of healthy controls received MR scan on 3.0T MR system. The T1WI data were collected. Using VBM method to compare the images of brain gray matter between two groups. The results were shown by statistical parametric mapping. Result: PD patients showed extensively decreased gray matter volume in widespread brain regions involving bilateral insular, parahippocampal gyrus, amygdale and right frontal, temporal, occipital, parietal lobes and left medial frontal gyrus. Conclusion: The VBM could thoroughly and accurately reflect the abnormal area of brain gray matter quantitatively which were common in PD patients, and it also provided the necessary neural imaging evidence for the pathological mechanism of PD patients with multiple system involvement.

导出引用

丁洪彬;田为中;张继;陈小云;夏建国;赵金丽;顾红梅. 帕金森病基于体素的MRI形态学研究[J]. 中国临床医学影像杂志. 2014, 25(3): 158-161

DING Hong-bin;TIAN Wei-zhong;ZHANG Ji;CHEN Xiao-yun;XIA Jian-guo;ZHAO Jin-li;GU Hong-mei. A voxel-based MRI morphometric study of Parkinson’s disease[J]. Journal of China Clinic Medical Imaging. 2014, 25(3): 158-161

中图分类号： Ｒ742.5 Ｒ445.2