摘要
目的：分析脑室旁结节状灰质异位（PNH）病人结节的位置与并发其他脑畸形的关系，以提高对本病的认识。方法：回顾性分析40例PNH病人的MRI表现，研究结节的位置、数量及单双侧分布与合并其他脑发育畸形的关系。结果：40例PNH中，前部型PNH 12例，后部型PNH 13例，弥漫型PNH 15例，合并大脑皮质发育畸形18例（45%），后部PNH较弥漫型PNH及前部PNH更容易合并大脑皮质发育异常，分别为12例、5例和1例，3组间有显著性差异（P＜0.001）。PNH合并胼胝体发育异常9例（22.5%），其中，弥漫型PNH 5例，后部型3例，前部型1例，3组间有显著性差异（P<0.05）。PNH合并脑白质减少17例，其中，前部PNH 2例，后部PNH 7例，弥漫型PNH 8例，前部型PNH合并脑白质减少发生率明显低于后两组，而后部型PNH与弥漫型PNH组间无显著性差异。结节的数量及单双侧分布与合并其他脑发育畸形无明显相关性。结论：PNH病人结节的位置与并发其他脑畸形有密切关系。后部型PNH更易合并大脑皮质发育异常，弥漫型PNH更易合并胼胝体发育异常。
Abstract
Objective: The purpose of this study was to determine whether specific associated brain abnormalities may be related to the location of periventricular nodular heterotopia(PNH) assessed by MR imaging. Methods: MR images of 40 patients previously diagnosed as PNH were retrospectively analyzed. Relationship between the location, numbers and sides of PNH and associated brain abnormalities were tested by using χ2 test. Results: Of the 40 PNH cases, anterior PNH(aPNH) was found in 12 patients(30%), posterior PNH(pPNH) in 13(32.5%), and diffuse PNH(dPNH) in 15(37.5%), cortical malformations were present in 18 patients. Associated cortical malformations were significantly more frequent in pPNH(92.3%) compared with aPNH(8.3%) and dPNH(33.3%), there were significant differences among the three groups(P<0.001). Abnormalities of the corpus callosum present in 9 patients, 5 cases in dPNH, 3 cases in pPNH and 1 case in aPNH, there were significant difference among the three groups(P<0.05). Reduced volume of cerebral white matter was noticed in 17 patients. A significant difference in the incidence of reduced white matter volume was found between aPNH(16.7%) and pPNH(53.8%, P<0.05) and between aPNH and dPNH(53.3%, P<0.05). Conclusion: PNH occurs in different locations that tend to be associated with different types of malformations. Among these location, pPNH is particularly distinct because of its significant association with malformations of the cerebral cortex and anomalies of corpus callosum.
关键词
脑疾病 /
磁共振成像
Key words
Brain diseases /
Magnetic resonance imaging
刘 斋;何 丽;董强强;祁宇轩;任庆云.
脑室旁结节状灰质异位：结节的位置与并发其他脑畸形的关系的MRI研究[J]. 中国临床医学影像杂志. 2014, 25(4): 229-232
LIU Zhai;HE Li;DONG Qiang-qiang;QI Yu-xuan;REN Qing-yun.
Location of periventricular nodular heterotopia and its relationship with associated brain abnormalities on MRI[J]. Journal of China Clinic Medical Imaging. 2014, 25(4): 229-232
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