摘要
目的：探讨卵巢肿瘤彩超血流指标阻力指数（RI）与卵巢组织中微血管密度（MVD）及促血管生成素-2（Ang-2）的相关性。方法：经手术病理证实的55例卵巢肿瘤患者，术前应用彩色多普勒超声观察卵巢肿瘤内部血流并测定RI值，术后对所切除卵巢肿瘤组织标本分别采用免疫组化法检测其组织中MVD及Ang-2表达，分析RI与MVD、Ang-2的相关性及与肿瘤性质分级之间的相关性。结果：卵巢肿瘤的良恶性与RI呈负相关（r=－0.577，P＜0.05）；MVD各组间呈正相关（r=0.750，P＜0.01）；RI与MVD呈显著负相关（r=－0.537，P＜0.05）；Ang-2与肿瘤分级呈显著正相关（r=0.573，P＜0.05）。结论：RI、MVD及Ang-2分别从不同角度反映了卵巢肿瘤中新生血管的形成，Ang-2有望作为卵巢癌的临床诊断指标之一，三者联合应用可对术前术后卵巢肿瘤的血管形成进行综合评价，为卵巢癌的抗血管新生治疗及预后评估提供有价值信息，具有较重要的临床预测价值。
Abstract
Objective: To evaluate the correlation between intratumoral blood flow index of resistance index(RI), assessed by color Doppler and microvascular density(MVD), together with expression of angiopoietin-2(Ang-2) in ovarian tumor. Methods: For 55 patients with ovarian tumor proved by pathologic histology examination, CDFI was performed preoperatively to detect the arterial blood flow signals, and the lowest RI values were recorded. MVD and the expression of Ang-2 were examined by immunohistochemical assay. Results: There was a significant negative correlation with RI for benign and malignant ovarian tumors(r=－0.577, P＜0.05). With the increase of tumor grade, MVD showed a significantly positive correlation(r=0.750, P＜0.01). There was a negative correlation between RI value and MVD(r=－0.537, P＜0.05). Ang-2 and tumor grade were significantly positively correlated(r=0.573, P＜0.05). Conclusions: Ang-2 is expected to be one of the indicators of clinical diagnosis of ovarian cancer. Combined application of RI, MVD and Ang-2 can comprehensively evaluate the angiogenesis of ovarian tumors before and after operation, which could be helpful in forecasting prognosis and therapy of ovarian cancer.
关键词
卵巢肿瘤 /
血管生成素2 /
超声检查 /
多普勒 /
彩色
Key words
Ovarian neoplasms /
Angiopoietin-2 /
Ultrasonography /
Doppler /
color
王娟娟;于 冰.
卵巢肿瘤彩超血流指标与微血管密度及促血管生成素的相关性[J]. 中国临床医学影像杂志. 2015, 26(10): 728-731
WANG Juan-juan;YU Bing.
Correlation between intratumoral flow assessed by color Doppler and microvascular density, together with expression of Ang-2 in ovarian tumor[J]. Journal of China Clinic Medical Imaging. 2015, 26(10): 728-731
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
