摘要
目的：观察实验性胫骨骨折愈合过程中，X线表现与骨密度、骨灰重及钙磷元素含量及病理变化的相关性，从而确定骨折愈合不同时期X线表现对于判定骨折愈合情况及指导临床康复治疗的意义。方法：取（250±10） g左右的大鼠60只，随机分为2组，实验组采用锯开法造成胫骨骨折模型，对照组不做任何处理。在术后2周和4周两个时间点进行采样，测试大鼠胫骨的骨密度、骨灰重，拍摄X线片以及病理切片观察，检测术后2周的钙磷含量。结果：2周时，实验组的骨密度、骨灰重均与正常组有显著性差异，钙磷元素在两组之间具有显著性差异。X线片显示实验组表现出骨折线模糊，病变端密度增高，少量骨痂形成，病理学切片显示实验组均有新生骨小梁形成。4周时，两组之间的骨密度、骨灰重均没有显著性差异，X线片显示实验组的骨痂明显，病理学切片显示骨小梁粗大，并逐步融合成板状骨。结论：骨折愈合过程中，X线表现与骨密度、骨灰重、钙磷元素、病理变化呈正相关，可以判定骨折愈合情况，并指导临床康复治疗。
Abstract
Objective: To observe in experimental tibial fracture healing process, the X-ray appearance and bone density, ash weight, calcium and phosphorus element content changes, so as to determine the X-ray features at different periods of fracture healing and to guide clinical rehabilitation treatment. Methods: Sixty rats of (250±10) g were randomly divided into 2 groups. Sawing accident was used to cause defect in the tibial fracture model in the experimental group. Control group received no treatment. Sampling was taken 2 weeks and 4 weeks after surgery to get X-ray films and bone density, ash weight, calcium and phosphorus element. Content of calcium and phosphorus was taken 2 weeks after operation. Results: After 2 weeks, bone density and ash weight, calcium and phosphorus element content showed significant difference betwee two groups. On X-ray films, the experimental group showed fuzzy fracture line, higher density lesions in the end and a small amount of callus formation. The pathology proved new bone trabecular formation. After 4 weeks, bone density and ash weight showed no significant differences between two groups. In the experimental group, callus was obvious on X-ray film. The pathology proved the trabecular bone became bulky and gradually merged into trabular bone. Conclusion: During fracture healing process, X-ray features are positively correlated with bone density, ash weight, calcium and phosphorus element content and pathological changes, which can determine fracture healing and guide clinical rehabilitation.
关键词
胫骨骨折 /
骨折愈合 /
骨密度 /
病理学 /
放射摄影术
Key words
Tibial fractures /
Fracture healing /
Bone density /
Pathology /
Radiography
赵书英;张万强;耿进朝;张景国.
实验性胫骨骨折愈合过程中的X线表现与骨密度、骨灰重及钙磷元素、病理学变化的相关性分析[J]. 中国临床医学影像杂志. 2015, 26(10): 736-739
ZHAO Shu-ying;ZHANG Wan-qiang;GENG Jin-chao;ZHANG Jing-guo.
Relevance analysis among X-ray image and bone density, ash weight, calcium and phosphorus element in the healing process of experimental tibial fracture[J]. Journal of China Clinic Medical Imaging. 2015, 26(10): 736-739
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