目的：评估超声造影和声触诊组织定量（VTQ）技术在甲状腺实性结节鉴别诊断中的价值。方法：对62例甲状腺实性结节性疾病患者，共96个结节（所有结节性质均经手术病理证实）行超声造影及VTQ检查，分析造影增强特点、时间-强度曲线参数、VTQ参数对甲状腺实性结节的诊断价值。结果：结节性甲状腺肿50个，甲状腺腺瘤15个，甲状腺乳头状癌31个，经卡方检验分析三者在增强程度、增强形态、周边增强方面有显著统计学差异（P<0.01）；在结节良、恶性鉴别方面，时间-强度曲线参数中RS-Ratio、IMAX-Ratio曲线下面积相对较大（P<0.01），VTQ参数中SWV、SWV-Ratio曲线下面积大于RS-Ratio、IMAX-Ratio。结论：超声造影增强模式对于鉴别结节的病理类型有重要的研究价值；VTQ技术在鉴别结节良、恶性方面研究价值要大于造影时间-曲线分析。

Objective: To assessment the diagnosis value of thyroid nodules by the contrast-enhanced ultrasound and the   virtual touch tissue quantification(VTQ) of acoustic radiation force impulse. Methods: Sixty-two patients with 96 thyroid solid nodules were enrolled into this prospective study(the final pathology diagnosis was confirmed by thyroidectomy). Analysis of contrast enhancement characteristics, intensity-time curve parameters combination VTQ parameters for differential diagnosis of thyroid benign and malignant nodules. Results: Fifty nodular goiter, 15 adenoma, 31 papillary carcinoma, according to Chi-square test analysis with three types, enhanced degree, enhanced shape, peripheral enhancement had significant statistical difference(P<0.01). In differential benign and malignant nodules aspect, the parameters of RS-Ratio, IMAX-Ratio AUC was relatively larger than others in the time-intensity curve(P<0.01), VTQ parameter SWV and SWV-Ratio AUC was larger than the RS-Ratio, IMAX-Ratio. Conclusion: The contrast-enhanced ultrasound pattern has great value in identification of thyroid nodule pathological type. The VTQ technology has greater value than the intensity-time curve in determination of whether a thyroid nodule was benign or malignant.