非小细胞肺癌患者原发病灶的糖代谢与化疗疗效的关系：一个以PERCIST为评价标准的初步研究

陈美洁; 李娜; 杜补林; 李亚明

中国临床医学影像杂志 ›› 2015, Vol. 26 ›› Issue (3) : 166-169.

论著

非小细胞肺癌患者原发病灶的糖代谢与化疗疗效的关系：一个以PERCIST为评价标准的初步研究

陈美洁，李娜，杜补林，李亚明

作者信息 +

The relationship between primary lesion glucose metabolism of NSCLC andchemotherapy: a preliminary study according to PERCIST criteria

CHEN Mei-jie, LI Na, DU Bu-lin, LI Ya-ming

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文章历史 +

摘要

目的：探究非小细胞肺癌患者原发病灶的糖代谢指标肿瘤代谢体积（MTV）和病变总体糖酵解（TLG）在化疗疗效预测中的价值。材料和方法：回顾性分析了18例Ⅲ~Ⅳ期非小细胞肺癌患者的临床资料。患者均接受以铂类为基础的一线化疗方案，并在治疗前后行18F-FDG PET/CT检查，分别以30% SUVmax及50% SUVmax为阈值测定MTV和TLG，疗效评价采用PERCIST标准。行秩和检验进行统计分析，ROC曲线分析诊断效能。结果：化疗治疗前后的指标的变化率ΔTLG30% SUVmax（u=73，P=0.003）、ΔMTV30% SUVmax（u=73，P=0.003）、ΔTLG50% SUVmax（u=65，P=0.025）、ΔMTV50% SUVmax（u=65，P=0.025）和ΔSUVmax（u=74，P=0.003）存在统计学意义，通过ROC曲线分析得出以30% SUVmax勾画，MTV和TLG的变化率分别为56.3%，62.2%时可以判别出化疗敏感者，而以50% SUVmax勾画时，MTV和TLG的变化率分别为63.3%和68.9%。结论：非小细胞肺癌患者化疗前后原发病灶的糖代谢指标TLG和MTV的变化率有助于筛选出化疗敏感者。

Abstract

Objective: The aim of this study was to investigate whether metabolic tumor volume(MTV) and total lesion glycolysis(TLG) of primary tumor could give a prediction of the sensitivity in non-small cell lung cancer chemotherapy. Method: Eighteen cases with phase Ⅲ~Ⅳ non-small cell lung cancer patients were reviewed retrospectively, who received platinum-based first-line chemotherapy and had 18F-FDG PET/CT examinations both before and after therapy. MTV and TLG were determined with two thresholds which were 30% SUVmax and 50% SUVmax, using PERCIST criteria to evaluate outcome. Statistical analysis included rank-sum test and ROC curve. Results: The change rates of indicators including ΔTLG30% SUVmax(u=73, P=0.003), ΔMTV30% SUVmax(u=73, P=0.003), ΔTLG50% SUVmax(u=65, P=0.025), ΔMTV50% SUVmax(u=65, P=0.025) and ΔSUVmax(u=74, P=0.003) were statistically significant. According to ROC curve, change rates of TLG and MTV were 62.2% and 56.3% respectively could discriminate sensitivity to chemotherapy with threshold of 30% SUVmax, as well as 68.9% and 63.3% with threshold of 50% SUVmax. Conclusions: The change rates of TLG and MTV of primary tumor in non-small cell lung cancer patients can contribute to filtering out chemotherapy sensitivity.

导出引用

陈美洁;李娜;杜补林;李亚明. 非小细胞肺癌患者原发病灶的糖代谢与化疗疗效的关系：一个以PERCIST为评价标准的初步研究[J]. 中国临床医学影像杂志. 2015, 26(3): 166-169

CHEN Mei-jie;LI Na;DU Bu-lin;LI Ya-ming. The relationship between primary lesion glucose metabolism of NSCLC andchemotherapy: a preliminary study according to PERCIST criteria[J]. Journal of China Clinic Medical Imaging. 2015, 26(3): 166-169

中图分类号： Ｒ734.2 Ｒ817.4