甲状腺良恶性结节超声造影特征与病理微血管密度的相关性研究

李小鹏; 张红丽; 何鑫; 周琦; 姜珏; 高亚; 雷小莹

中国临床医学影像杂志 ›› 2015, Vol. 26 ›› Issue (9) : 631-634.

论著

甲状腺良恶性结节超声造影特征与病理微血管密度的相关性研究

李小鹏，张红丽，何鑫，周琦，姜珏，高亚，雷小莹

作者信息 +

Correlation between contrast-enhanced ultrasound characteristics and microvessel density ofbenign and malignant thyroid nodules

LI Xiao-peng, ZHANG Hong-li, HE Xin, ZHOU Qi, JIANG Jue, GAO Ya, LEI Xiao-ying

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摘要

目的：探讨甲状腺良恶性结节超声造影特征及定量参数与病理微血管密度（MVD）的相关性，为甲状腺良恶性结节的不同灌注特点提供病理依据。方法：回顾性分析122例甲状腺结节的超声造影表现，进行时间-强度曲线（TIC）分析。对术后标本行免疫组化CD31、CD34染色后计数MVD，对甲状腺结节超声造影定量参数与MVD计数进行相关性分析。结果：在超声造影增强达峰时，甲状腺癌多表现为不均匀低增强，结节性甲状腺肿多表现为等增强，腺瘤表现为高增强。甲状腺癌组IMAX、MVD均低于结节性甲状腺肿及腺瘤组，差异均具有统计学意义（P＜0.05）。甲状腺结节超声造影定量参数中IMAX与MVD呈显著正相关（rCD31=0.814，PCD31＜0.01；rCD34=0.803，PCD34＜0.01）。结论：低增强是诊断甲状腺癌重要的增强模式，甲状腺癌呈乏血供状态。

Abstract

Objective: To investigate the performance of thyroid nodules with contrast-enhanced ultrasound(CEUS) and the correlation between CEUS quantitative parameters and microvessel density(MVD), to provide pathologic basis for different perfusion characteristics of benign and malignant thyroid nodules. Methods: The CEUS features of 122 patients with thyroid nodules were retrospectively analyzed. The time-intensity curves(TIC) were analyzed by TomTec software. Immunohistochemical staining were performed to evaluate the MVD in the surgical specimens, and the correlation of quantitative parameters with MVD were assessed. Results: When the ultrasound contrast enhancement to the peak, the thyroid carcinoma showed homogeneous hypo-enhancement, nodular goiter showed iso-enhancement, thyroid adenoma showed hyper-enhancement. IMAX and MVD of thyroid carcinoma were lower than nodular goiter and thyroid adenoma, and the differences were statistically significant(P<0.05). A positive correlation existed between the IMAX and MVD(rCD31=0.814，PCD31＜0.01; rCD34=0.803, PCD34＜0.01). Conclusions: Hypo-enhancement was the important CEUS enhancement patterns to diagnose thyroid carcinoma, thyroid carcinoma was lack of blood supply.

导出引用

李小鹏;张红丽;何鑫;周琦;姜珏;高亚;雷小莹. 甲状腺良恶性结节超声造影特征与病理微血管密度的相关性研究[J]. 中国临床医学影像杂志. 2015, 26(9): 631-634

LI Xiao-peng;ZHANG Hong-li;HE Xin;ZHOU Qi;JIANG Jue;GAO Ya;LEI Xiao-ying. Correlation between contrast-enhanced ultrasound characteristics and microvessel density ofbenign and malignant thyroid nodules[J]. Journal of China Clinic Medical Imaging. 2015, 26(9): 631-634

中图分类号： Ｒ736.1 Ｒ581 R445.1