摘要
目的：评价3D磁共振弹性成像（MRE）评估健康志愿者胰腺弹性值的可行性，探讨正常成人胰腺磁共振弹性值测量的参考范围。方法：选取21名无胰腺及肝脏相关疾病的健康志愿者，采用GE 3.0T MR快速平面回波（EPI）序列定量测量胰腺弹性值，评价胰腺不同部位（头、体、尾）的平均弹性值，振动频率采用40 Hz及60 Hz。结果：40 Hz时，胰腺总体平均弹性值为（1.11±0.16） kPa，肝脏为（1.62±0.26） kPa，比值为0.69。60 Hz时的胰腺、肝脏弹性值分别为（2.08±0.35） kPa及（2.27±0.34） kPa，二者比值为0.92。两种频率下胰腺的不同部位弹性值的差异均无统计学意义（单因素方差分析，P值均＞0.05）。40 Hz的变异系数（CV）较60 Hz低（分别为13.91%~20.91%，18.84%~21.84%；P＜0.05）。结论：低频3D磁共振弹性成像可获得稳定的健康胰腺弹性值（40 Hz优于60 Hz），同一个体胰腺不同部位的弹性值无差别。
Abstract
Objective: To evaluate the feasibility of using 3D magnetic resonance elastography(3D MRE) to assess the pancreatic stiffness in healthy volunteers. Methods: Twenty-one volunteers without pancreatic-related diseases underwent GE 3.0T MR exams using a multi-slice EPI pulse sequence with low-frequency vibrations(40 and 60 Hz). The mean stiffness in three pancreatic subregions(head, body and tail) and the corresponding liver stiffness were calculated. Results: The mean stiffness(average of values obtained in different pancreatic subregions) was (1.11±0.16) kPa at 40 Hz, and (2.08±0.31) kPa at 60 Hz. The corresponding liver stiffness was (1.62±0.26) kPa at 40 Hz(mean pancreas-to-liver stiffness ratio: 0.69), and (2.27±0.34) kPa at 60 Hz(mean ratio: 0.92). The mean stiffness in three pancreatic subregions have no significant differences(P>0.05). The mean CV for each pancreatic subregion was lower at 40 Hz than 60 Hz(P<0.05 for all subregions, range: 13.91%~20.91% at 40 Hz and 18.84%~21.84% at 60 Hz). Conclusion: 3D MRE can provide pancreas stiffness measurements in healthy people, with lower variation at 40 Hz. There was no difference of stiffness among different pancreatic subregions.
关键词
胰腺 /
磁共振成像
Key words
Pancreas /
Magnetic resonance imaging
安 訸;石 喻;郭启勇.
3D磁共振弹性成像评估健康志愿者的胰腺弹性值的可行性研究[J]. 中国临床医学影像杂志. 2015, 26(9): 646-649
AN He;SHI Yu;GUO Qi-yong.
Feasibility of using 3D elastography to assess pancreatic stiffness in healthy volunteers[J]. Journal of China Clinic Medical Imaging. 2015, 26(9): 646-649
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