目的：探讨18F-FDG PET/CT全身显像在儿童肝母细胞瘤（HB）中的应用价值。方法：回顾性分析经穿刺活检或/及手术病理确诊的15例儿童HB患者的PET/CT影像及临床资料，总结该病的PET/CT表现特点及其鉴别诊断要点。结果：15例HB患者PET/CT均表现为低密度或混杂密度肿块（8例肿块内见散在钙化灶）伴代谢增高；同时PET/CT发现4例肺转移、1例肺及骨转移。结论：PET/CT检查可安全、无创的用于儿童（包括婴幼儿）显像，且儿童肝母细胞瘤PET/CT具有一定的特征性表现，有助于肝母细胞瘤的诊断和协助临床分期。
Abstract
Objective: To investigate the diagnostic value of 18F-FDG PET/CT in pediatric hepatoblastoma(HB). Methods: We retrospectively analyzed the PET/CT images and clinical data of 15 pediatric HB patients proved by biopsy or/and histopathology after operation, and summarized the PET/CT features of HB and the key points of its differential diagnosis. Results: Tumors showed low or mixed density with high metabolism. Calcifications were found in 8 of the 15 patients. Four patients were found with pulmonary metastases and one patient was found with both pulmonary and bone metastases by whole body PET/CT scan. Conclusion: PET/CT scan can be safely and noninvasively used in children(including infants). HB has certain characteristic findings on PET/CT, whicn is very helpful to the diagnosis and clinical staging of HB.
关键词
肝肿瘤 /
肝胚细胞瘤 /
正电子发射断层显像术 /
体层摄影术 /
螺旋计算机
Key words
Liver neoplasms /
Hepatoblastoma /
Positron-emission tomography /
Tomography, spiral computed
中图分类号：
Ｒ735.7
Ｒ817.4
R814.42
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参考文献
[1]Dezsofi A, McLin V, Hadzic N. Hepatic neoplasms in children: A focus on differential diagnosis[J]. Clin Res Hepatol Gastroenterol, 2014, 38(4): 399-402.
[2]Meyers RL, Tiao G, de Ville de Goyet J, et al. Hepatoblastoma state of the art: Pre-treatment extent of disease, surgical resection guidelines and the role of liver transplantation[J]. Curr Opin Pediatr, 2014, 26(1): 29-36.
[3]Spector LG, Birch J. The epidemiology of hepatoblastoma[J]. Pediatr Blood Cancer, 2012, 59(5): 776-779.
[4]Fernandez-Pineda I, Cabello-Laureano R. Differential diagnosis and management of liver tumors in infants[J]. World J Hepatol, 2014, 6(7): 486-495.
[5]杨富阁，高剑波，梁盼. 儿童原发性肝细胞肝癌的CT表现及鉴别诊断[J]. 临床放射学杂志，2014，33（8）：1248-1251.
[6]McCarville MB, Roebuck DJ. Diagnosis and staging of hepatoblastoma: Imaging aspects[J]. Pediatr Blood Cancer, 2012, 59(5): 793-799.
