目的：经颅脑超声观察新生儿脑岛形态特征及其与矫正胎龄（CGA）的关系，并建立新生儿脑岛正常值范围。方法：经颅脑前囟矢状面扫描至脑岛层面观察212例CGA 28～43周单胎新生儿脑岛的形态特征并在脑岛层面测量其面积与周长，采用回归分析评价各测量值与CGA的关系以组内相关系数ICC及Bland-Altman检验评价测量结果的重复性和一致性。结果：新生儿的脑岛呈倒三角形，岛叶沟回自前下向后上部放射状延伸呈花瓣状，正常的新生儿脑岛面积、周长均随CGA而增大，其回归方程如下：脑岛面积（mm2）＝183.7CGA-2 766.1（r2=0.545，P<0.01），脑岛周长（mm）=12.91CGA-243.66（r2=0.393，P<0.01），测量的重复性和一致性均较高。结论：经颅脑超声观测新生儿脑岛可以成为一种评价新生儿脑岛的发育情况的常规手段。
Abstract
Objective: To observe neonatal insula development situation and clinical significance by head ultrasound. Methods: Morphological characteristics and areas and perimeters of 212 cases of neonatal insula(at 28～43 weeks’ corrected gestational age(CGA)) were observed and measured by head ultrasound and their correlation with CGA were evaluated with regression analysis. The repeatability and consistency were analyzed with ICC and Bland-Altman analysis. Results: Neonatal insula was inverted triangle in shape, insula gyrus were radially extended upwards, which looked like flower petal. The area and perimeter of neonatal insula strongly correlated with CGA. The regression equations were as follows: area of insula(mm2)=183.7CGA-2 766.1(r2=0.545, P<0.01), perimeter of insula(mm)=12.91CGA-243.66(r2=0.393, P<0.01). The repeatability and consistency of data obtained were all perfect. Conclusion: Transcranial ultrasound can become a routine means in assessing the development of neonatal insula.
关键词
脑 /
婴儿 /
新生 /
超声检查 /
多普勒 /
经颅
Key words
Brain /
Infant, newborn /
Ultrasonography, Doppler, transcranial
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