目的：探讨酸刺激前后MR扩散加权成像（Diffusion-weighted imaging，DWI）对于评价干燥综合征（Sj?觟gren’s syndrome，SS）患者腮腺功能的价值。方法：收集口干、临床确诊为SS的患者14例（病例组），招募年龄及性别匹配的健康志愿者12例作为对照组。先行腮腺常规MRI及静息态DWI，酸刺激（口含维生素C丸200 mg）后再连续行DWI 15次，间隔2.5 min。比较静息态两组腮腺ADC值有无差异；比较酸刺激后两组ADC值的变化趋势。结果：静息态病例组腮腺ADC值低于对照组（分别为（0.77±0.15）×10-3 mm2/s和（0.93±0.28）×10-3 mm2/s，P＜0.05）。酸刺激后对照组先迅速升高，然后逐渐达到峰值，病例组先迅速降低，然后缓慢升高到峰值，病例组达峰时间晚于对照组（分别为27.5 min和22.5 min，P＜0.05）、峰值和变化率低于对照组（P＜0.05）。结论：SS患者腮腺ADC值降低，酸刺激后ADC值随时间变化不同于健康对照组。酸刺激前后腮腺DWI可能成为评价SS患者腮腺功能的手段。
Abstract
Objective: To investigate the value of MR diffusion-weighted imaging(DWI) for evaluating the function of parotid glands in patients with Sj?觟gren’s syndrome(SS) before and after acid stimulation. Methods: Fourteen patients with SS(patient group) and age and sex-matched 12 healthy volunteers(control group) were examined with parotid gland conventional sequences and DWI sequence before acid stimulation. After the acid stimulation with Vc pill 200 mg, DWI sequence was repeated 15 times, interval 2.5 min. We compared the difference between the two groups in resting state; then compared the changes of ADC values after stimulation. Results: The ADC values of the patient group were lower than that of the control group before stimulation((0.77±0.15)×10-3 mm2/s and (0.93±0.28)×10-3 mm2/s, respectively, P＜0.05). The ADC values of the control group increased rapidly after stimulation, then reached the peak gradually. The ADC values of the patient group decreased rapidly after stimulation, then increased to the peak slowly. The time to peak(Tmax) of the patient group was later than that of the control group(27.5 min and 22.5 min, respectively, P＜0.05), the peak value and change rate were lower than that of the control group(P＜0.05). Conclusion: The ADC values of parotid glands in patients with SS decreased, and changed with time after acid stimulation, which were different from that in healthy control group. MR DWI can evaluate the function of parotid glands in patients with SS before and after acid stimulation.
关键词
干燥综合征 /
腮腺疾病 /
磁共振成像
Key words
Sjogren’s syndrome /
Parotid diseases /
Magnetic resonance imaging
中图分类号：
Ｒ442.8
Ｒ781.7
Ｒ445.2
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