目的：探讨声触诊组织量化（VTQ）技术在乳腺实性小结节良恶性鉴别诊断中的应用价值。方法：应用常规二维超声（CUS）对76例患者84个直径≤1 cm的乳腺实性小结节的声像图特征进行评价，并用VTQ技术检测其VTQ值。通过VTQ值对乳腺实性小结节进行硬度评估。以病理诊断为金标准，分别对常规二维超声和VTQ技术进行比较，并绘制VTQ值诊断乳腺恶性结节的ROC曲线，找出VTQ值诊断恶性小结节的最佳截点。结果：常规二维超声诊断乳腺恶性小结节的敏感性为77.3%，特异性为80.0%。经ROC曲线检验，以VTQ值2.89 m/s为截点诊断乳腺恶性小结节的敏感性86.4%，特异性92.5%。结论：VTQ技术相较于常规二维超声能更加客观的反映乳腺病灶的硬度信息，对乳腺实性小结节良恶性的鉴别诊断具有较高的应用价值。

Objective: To investigate the application value of virtual touch tissue quantification(VTQ) in the diagnosis of small solid breast nodules. Methods: The conventional ultrasonography(CUS) and VTQ were performed on 84 small solid breast nodules(diameter≤1 cm) of 76 patients. VTQ values were obtained and analyzed. Based on VTQ values of the small solid nodules, the hardness of the lesions were evaluated. With the pathological diagnosis as the gold standard, sensitivity and specificity of CUS and VTQ were compared. VTQ values of the ROC curve in the diagnosis of breast malignant nodules were sketched so as to explore the optimal cut-off point of VTQ values in the diagnosis of small malignant nodules. Result: CUS in the diagnosis of small solid nodules, the sensitivity and specificity were 77.3%, 80.0%. By the ROC curve test, the VTQ value of 2.89 m/s in the diagnosis of breast malignant nodules was designated as the cut-off point, with the sensitivity of 86.4%, specificity of 92.5%. Conclusion: VTQ technique can provide the hardness information of breast lesions, which has higher application value in the differential diagnosis of small solid breast nodules than CUS.