目的：探讨人类不同年龄组颌下腺的MRI体积、信号强度及ADC值增龄性变化的规律。方法：测量4个年龄组共300例受试者600侧正常颌下腺的体积、T1WI、T2WI和增强T1WI信号强度与ADC值。测量脑脊液的信号强度与ADC值作为对照，并计算颌下腺T1WI、T2WI和增强T1WI相对信号强度。结果：颌下腺的体积随增龄的变化不显著（P＞0.05）。未成年组与中年组颌下腺的ADC值具有显著性差异（P＜0.01）。男性颌下腺的平均体积显著高于女性（t=4.576，P＜0.01）。不同年龄组间脑脊液的各项参数值均无显著性差异（P＞0.05）。左右两侧涎腺的各参数间均无显著性差异（P＞0.05）。结论：MRI能定量评价正常颌下腺形态特征与功能特征的增龄性改变，可以为涎腺老龄化研究和颌下腺疾病的诊断与鉴别诊断提供基线参考依据。
Abstract
Objective: To explore the age-related characteristics of volumes, T1WI, T2WI, and contrast T1WI signal intensities(SI) and apparent diffusion coefficients(ADC) of submandibular glands. Methods: Three hundred subjects with normal submandibular glands were divided into four different age groups and examined with a 1.5T MR unit. T1WI, T2WI, contrast T1WI and diffusion-weighted MR images(DW MRI) were obtained, and bilateral submandibular glands were segmented manually. Relative signal intensities(RSI) of T1WI, T2WI and enhanced-T1WI and value of ADC were calculated. Results: There was no significance in volumes of submandibular between four different age groups(P＞0.05). The ADC of submandibular glands showed a significant difference between the minority and middle age group(P＜0.01). The mean submandibular gland volume was higher in males demonstrating a significant difference between genders(t=4.576, P＜0.01). No significant differences was observed in all parameters of CSF among four groups(P＞0.05). There also was no significant difference between right and left glands in all parameters(P＞0.05). Conclusion: Quantitative evaluation of MRI on aging morphological and functional changes of submandibular glands can provide baseline references for salivary glands aging research and differential diagnosis of submandibular gland diseases.
关键词
颌下腺 /
磁共振成像
Key words
Submandibular gland /
Magnetic resonance imaging
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参考文献
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基金
江苏省临床医学科技专项（BL2014040）；苏州市科技发展计划项目（SYSD2011096）。
