目的：应用二维斑点追踪显像技术探讨急性心力衰竭患者新活素治疗疗效的价值。方法：80例急性心力衰竭患者随机分为研究组（新活素）和对照组各40例。两组患者均给予常规心力衰竭治疗，研究组在常规治疗的基础上加用新活素，比较两组患者的左心室射血分数（LVEF）、左室长轴平均总应变（GLS-Avg）、左心室扭转角度峰值（Ptw）、解旋速度峰值（PutwV）、扭转角度达峰时间（TPK）。结果：经治疗后两组患者的LVEF、GLS-Avg、Ptw、PutwV均增加，TPK均延迟，不过研究组的各参数变化程度明显高于对照组，差异均有统计学意义（P＜0．05）。研究组治疗后各参数均有所改善，差异有统计学意义（P<0.05）。对照组治疗后各参数均有所改善，但与治疗前比较差异无统计学意义（P>0.05）。结论：在临床上，新活素对于患者的治疗具有积极有效的作用。二维斑点追踪显像技术可为新活素疗效评定提供一种无创手段。

Objective: To explore value of rhBNP treatment efficacy in patients with acute heart failure by using two-dimensional speckle tracking imaging techniques. Methods: Eighty cases of acute heart failure patients were randomized into observe group(rhBNP) and control group(n=40 each), all the patients were treated with traditional heart failure treatment, but the observe group received rhBNP. Two groups of patients with left ventricular ejection fraction(LVEF), left ventricular long axis of the average total strain(GLS-Avg), peak twist(Ptw）, peak untwist velocity(PutwV), and the time to peak twist(TPK) were observed. Results: After treatment, the LVEF, GLS-Avg absolute value, Ptw and PutwV of patients in two groups were increased, but the increasing degree of the observation group was significantly higher than those of the control group, the difference was statistically significant(P<0．05). TPK of patients in two groups were delayed, but the delaying degree of the observation group was significantly higher than those of the control group, the difference was statistically significant(P<0．05). The parameters in the observe group after treatment has improved, the difference was statistically significant(P<0.05). The parameters in the control group after treatment were improved, but there was no statistically significant difference compared with before treatment(P>0.05). Conclusion: rhBNP has a positive and efficient effects on the patients in clinical. At the same time, 2D-STI can provide an effective and noninvasive method for clinical evaluation of left ventricular function．