目的：比较应力式超声弹性成像（UE）与光散射断层成像（DOT）对≤2.00 cm乳腺癌的诊断价值。方法：对92例患者共112个乳腺病灶进行UE和DOT检查。以病理结果作为金标准，绘制ROC曲线，评价两种技术的诊断价值。结果：112个乳腺病灶中，良性74个，恶性38个。UE和总血红蛋白浓度（TTHC）的曲线下面积分别为0.928（95%CI：0.864～0.968）、0.851（95%CI：0.771～0.911），差异无统计学意义（Z=1.698，P=0.089）。UE诊断的敏感度为84.21%（32/38），特异度为90.54%（67/74），准确率为88.39%（99/112）。TTHC诊断阈值为131.88 μmol/L，敏感度为86.84%（33/38），特异度为82.43%（61/74），准确率为83.93%（94/112）。结论：UE和DOT两种技术均可为≤2.00 cm乳腺癌的早期诊断提供有价值的参考信息。
Abstract
Objective: To evaluate the diagnostic performance of strain ultrasound elastography(UE) and diffused optical tomography(DOT) in the diagnosis of small breast cancer(≤2.00 cm). Methods: UE and DOT were performed on 112 breast lesions in 92 patients. Taking pathologic diagnosis as gold standard, receiver operating characteristic(ROC) curves were obtained to evaluate the diagnosis value of the two approaches. Results: There were 38 benign and 74 malignant lesions． Area under the curve of UE and DOT were 0.928(95%CI: 0.864～0.968) and 0.851(95%CI: 0.771～0.911), respectively. There was no significant differences(Z=1.698, P=0.089). The sensitivity, specificity and accuracy in the diagnosis of breast cancer for UE were 84.21%(32/38), 90.54%(67/74) and 88.39%(99/112), respectively. With a cutoff value of 131.88 μmol/L for the total tumor hemoglobin concentrations(TTHC), the sensitivity, specificity and accuracy for DOT were 86.84%(33/38), 82.43%(61/74) and 83.93%(94/112), respectively. Conclusion: UE and DOT are both useful for providing valuable reference for early diagnosis of small breast cancer(≤2.00 cm).
关键词
乳腺肿瘤 /
超声检查
Key words
Breast neoplasms /
Ultrasonography
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基金
国家自然科学基金资助项目（No.81571686）
