目的：研究口干患者腮腺不同程度损伤的唾液腺动态显像的影像特征，结合摄取率95%可信区间综合评估腮腺摄取功能的损伤程度。材料与方法：搜集2013年10月—2014年11月于潍坊医学院附属医院核医学科行唾液腺动态显像的口干患者68例及18例健康志愿者（对照组），对两组受检者分别进行99TcmO4-唾液腺动态显像，观察腮腺动态影像及时间-放射性曲线并据此分组，计算各组摄取率及其95%可信区间，并对观察组各组和对照组的摄取率进行比较。结果：腮腺摄取功能轻、中与重损组的UR2、UR8及UR15均低于对照组且差异有统计学意义（P<0.05）；其中摄取功能中损与重损组的UR2、UR8及UR15均低于轻损组，差异有统计学意义（P<0.05）；与摄取功能中损组比较，重损组腮腺的UR8及UR15降低，差异有统计学意义（P<0.05），而参数UR2无显著性差异（P>0.05）。进一步结合其95%可信区间，诊断UR2 1.48%~1.66%或UR8 2.05%~2.49%时为轻损，UR8 1.64%~2.05%或UR15 2.14%~2.64%时为中损，UR15<2.14%时为重损。结论：唾液腺动态影像特征能初步评估腮腺摄取功能，参数UR2、UR8及UR15可定量分析其损伤程度，结合摄取率95%可信区间可简明、准确的评价口干患者腮腺摄取功能的损伤程度。
Abstract
Objective: To investigate the salivary gland scintigraphy(SGS) image feature of the damage degree of parotid gland in patients with xerostomia, and to comprehensively evaluate the damage degree of parotid gland uptake function combined with the 95% confidence interval. Materials and Methods: 68 patients with xerostomia and 18 healthy volunteers(control group) collected in Affiliated Hospital of Weifang Medical College from October 2013 to November 2014 were examined with 99TcmO4- salivary gland dynamic imaging. The dynamic images of parotid gland and the time-radioactive curve were observed and grouped, and the uptake rate and 95% confidence interval were calculated, then the uptake rate of the observation group and the control group were compared. Results: The UR2, UR8 and UR15 in the mild injury group, moderate injury group and severe injury group were significantly lower than those in the control group(P＜0.05). In the moderate injury group and severe injury group, the UR2, UR8 and UR15 were significantly lower than those in the mild injury group(P＜0.05). Compared with the moderate injury group, the UR8 and UR15 in the severe group were significantly decreased(P＜0.05), while the UR2 was no significant difference(P>0.05). And combined with its 95% confidence interval, UR2 1.48%~1.66% or UR8 2.05%~2.49% was diagnosed with minor injury, UR8 1.64%~2.05% or UR15 2.14%~2.64% with medium injury, UR15<2.14% with severe injury. Conclusion: The characteristic of SGS image can preliminarily evaluate the intake function of parotid gland, and parameter UR2, UR8 and UR15 can be used for quantitative analysis of the damage degree, combined with its 95% confidence interval can concisely and accurately assess the damage degree of uptake function of parotid gland in patients with xerostomia.
关键词
腮腺疾病；口腔干燥；体层摄影术 /
发射型计算机 /
单光子
Key words
Parotid diseases /
Xerostomia /
Tomography, emisson-computed, single-photon
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