目的：探讨多烯紫杉醇联合碘化油介入方案（多西他赛治疗方案）治疗肝癌的临床疗效。方法：将原发中晚期肝癌43例按患者病例单双号随机分为A、B两组。A组（多西他赛治疗方案）：22例，先注入地塞米松10 mg预防过敏反应，然后将多西他赛60 mg/m2溶于100 mL 0.9%生理盐水中缓慢推注，再将5-FU 250 mg与5～20 mL碘油的混悬液缓慢注入栓塞，直至碘油在瘤灶内沉积浓密或血流缓慢。B组（常规化疗治疗方案组）：21例，表柔比星（EADM）40～60 mg/m2、丝裂霉素（MMC）8 mg/m2、顺铂（DDP）60 mg/m2、羟基喜树碱（HCPT）20 mg/m2，以上化疗药物根据患者病情选出几种组合碘油。并观察比较肿瘤治疗后的近期疗效、患者生存期及并发症。结果：A组与B组6、12月生存率分别为94.5%、48.9%和91．6%、37.6%，两组生存率比较差异有显著性（P<O．05）。两组并发症无明显差别。结论：多西他赛方案治疗原发性肝癌较常规化疗方案组能更好的改善患者的近期生存质量，能在一定程度上延长患者的生存期。
Abstract
Objective: To explore the clinical effect of intervention programme using docetaxel combined with iodized oil in the treatment of liver cancer. Methods: Forty-three cases of primary advanced liver cancer were randomly divided into group A(docetaxel group with 22 cases) and group B (conventional therapy group with 21 cases). The patients in group A received injection of dexamethasone 10 mg to prevent allergic reaction firstly, and then docetaxel 60 mg/m2 dissolved in 100 mL of 0.9% saline was infused slowly. And finally transarterial embolism was performed with slow injection of 5-FU 250 mg and 5~20 mL iodine suspension until iodine oil deposited in the tumor foci was thick or blood flow slowed down. Patients in group B were treated with different combination of epirubicin(EADM) 40~60 mg/m2, mitomycin(MMC) 8 mg/m2, cisplatin(DDP) 60 mg/m2 or hydroxy camptothecin(HCPT) 20 mg/m2 according to the patients’ conditions, together with iodine oil. Then the short-term efficacy, the patient’s survival and the complications after treatment were compared. Results: The 6 and 12 months survival rates were 94.5%, 48.9% and 91.6%, 37.6% respectively for group A and group B, and the survival rates of the two groups were significantly different(P<0.05), while the complications in the two groups were not significantly different. Conclusion: Docetaxel-containing regimen can improve the life quality of patients with primary liver cancer compared with conventional chemotherapy treatment, and can prolong the survival of patients to a certain extent.
关键词
肝肿瘤；碘化油；栓塞 /
治疗性；体层摄影术 /
螺旋计算机
Key words
Liver noeplasms /
Iodized oil /
Embolization, therapeutic /
Tomography, spiral computed
中图分类号：
Ｒ735.7
R815
Ｒ814.42
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