目的：探讨抑郁症及一级亲属静息状态下脑区的局部一致性（ReHo）的特点及差异，以了解抑郁症患者的脑功能状态。方法：前瞻性研究15例抑郁症患者（抑郁症组）、15例抑郁症一级亲属（一级亲属组）、15名健康志愿者（对照组），分别进行3.0T静息态脑功能磁共振（fMRI）成像。结果：与一级亲属组相比，抑郁症组的右侧额中回、右侧中央前回、右侧额上回、右侧前扣带回、右侧脑岛、左侧壳核、左侧颞上回、左侧颞中回、左侧背侧扣带回的ReHo值显著性降低（P<0.05）；与对照组相比，抑郁症组的左侧中央后回、左侧颞上回、左侧颞中回、左侧额下回、左侧眶额叶皮质、左侧背侧扣带回、右侧中央前回、右侧内侧前额叶皮质、右侧额上回、双侧额中回、双侧前扣带回、右侧脑岛的ReHo值显著减低（P<0.05）；与对照组相比，一级亲属组的左侧小脑前叶、左侧颞上回、左侧额下回、左侧眶额叶皮质、左侧额上回、左侧背侧扣带回、左侧脑岛、右侧额中回、右侧前扣带回的ReHo值显著降低（P<0.05）。结论：抑郁症患者及一级亲属脑区均存在广泛的ReHo异常，这些异常的脑区可能与抑郁症认知网络障碍及情感低落相关。
Abstract
Objective: We studied the characteristics and differences of the regional homogeneity(ReHo) of the major depression disorder(MDD) and their first-degree relatives in the resting state by functional magnetic resonance imaging(fMRI), in order to understand the early changes of the brain function in patients with MDD. Methods: The experiments were performed by 3.0T fMRI in 15 patients with MDD(the depression group), 15 first-degree relatives of MDD(the first-degree relatives group) and 15 healthy volunteers(the control group). A statistics analysis of ReHo was performed subsequently. Results: The ReHo values measured in right middle frontal gyrus, right precentral gyrus, right superior frontal gyrus, right anterior cingulate cortex, right insular, left putamen, left superior temporal gyrus, left middle temporal gyrus, left dorsal cingulate cortex of MDD group were significantly lower than those of the first-degree relatives group(P<0.05). The ReHo values measured in left postcentral gyrus, left superior temporal gyrus, left middle temporal gyrus, left inferior frontal gyrus, left orbitofrontal cortex, left dorsal cingulate cortex, right precentral gyrus, right medial prefrontal cortex, right superior frontal gyrus, the middle frontal gyrus, the anterior cingulate cortex, right insular of MDD group were significantly lower than those of the control group(P<0.05). The ReHo values measured in left anterior lobe of cerebellum, left middle temporal gyrus, left inferior frontal gyrus, left orbitofrontal cortex, left superior frontal gyrus, left dorsal cingulate cortex, left insular, right middle frontal gyrus, right anterior cingulate cortex of the first-degree relatives group were significantly lower than those of the control group(P<0.05). Conclusion: With the widespread abnormal ReHo values of brain in MDD and first-degree relatives, we can get a hypothesis that these abnormalities may be associated with cognitive network disorders and emotional distress in MDD.
关键词
抑郁症 /
磁共振成像
Key words
Depressive disorder /
Magnetic resonance imaging
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基金
山东省自然科学基金（编号ZR2016HL40）。
