目的：探讨不同病理阶段肺腺癌性磨玻璃结节（GGN）的18F-FDG PET/CT影像学特征。方法：依据病理将68例病灶分为浸润前病变（不典型腺瘤样增生（AAH）和原位腺癌（AIS））、微浸润腺癌（MIA）和浸润性腺癌（IAC）3组，回顾性分析各组GGN的实性成分比例、形态学、大小和SUVmax值，并对数据的差异分别进行统计分析。结果：从浸润前病变、MIA至IAC， GGN实性成分比例、分叶毛刺征比率、大小、SUVmax逐渐增高。浸润前病变组与MIA组是否纯磨玻璃结节及大小的差异有统计学意义（P＜0.05）。MIA组与IAC组的实性成分比例、分叶毛刺征比率、大小及SUVmax的差异均有统计学意义（均P＜0.05）。结论：综合分析GGN的18F-FDG PET/CT影像学特征，可对不同病理阶段腺癌性GGN的诊断和鉴别诊断提供帮助。
Abstract
Objective: To investigate and control analyse the 18F-FDG PET/CT features of lung adenocarcinoma presenting as isolated ground-glass nodules(GGN). Methods: Sixty-eight lung adenocarcinoma presenting as isolated GGN confirmed by surgery pathology were included in this study． The lesions were divided into three groups: precancerous lesions(atypical adenomatous hyperplasia(AAH) and adenocarcinoma in situ(AIS)), microinvasive adenocarcinoma(MIA), invasive adenocarcinoma(IAC).The lesion size, solid portions, morphological feature, metabolism characteristic on the preoperative 18F-FDG PET/CT images in the three groups were analyzed and compared with pathological results． The data were statistically analyzed using SPSS 17.0． Results: The lesion size, solid portions, morphological feature, SUVmax gradually increased from precancerous lesions to IAC． There were statistically significant differences in lesion size and solid portions between the precancerous lesions and MIA groups(P<0.05). There were statistically significant differences in the lesion size, solid portions, morphological feature and metabolism characteristic between MIA and IAC groups(P<0.05, all)． Conclusion: Comprehensive analysis of the 18F-FDG PET/CT image features of GGN, may be helpful for the diagnosis and distinguish diagnosis of precancerous lesions, MIA and IAC．
关键词
肺肿瘤；正电子发射断层显像术；体层摄影术 /
X线计算机
Key words
Lung neoplasms /
Positron-emission tomography /
Tomography, X-ray computed
中图分类号：
Ｒ734.2
Ｒ814.42
Ｒ817.4
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