目的：通过比较MELD评分及CTP评分与肝脏体积的相关性，确定二者评估乙型肝炎肝硬化肝脏储备功能的准确性。方法：选择本院经临床综合诊断确诊的乙型肝炎肝硬化患者52例。利用Philips 256层iCT测量其总肝体积，并计算标准化后总肝体积（SLV）。根据实验室及临床资料，计算MELD和CTP评分，分别绘制MELD评分、 CTP评分与SLV之间散点图，比较SLV与MELD评分、CTP评分相关性。结果：52例肝硬化患者肝脏总体积为（989.4±293.7） cm3，SLV为（532.3±143.2） cm3/m2。MELD评分为14.37±6.19，CTP评分为8.71±2.80，SLV与Child评分、MELD评分分值之间均呈显著负相关，两者相关系数分别为RChild=-0.685（P<0.05），RMELD=-0.82（P<0.05），决定系数分别为0.47、0.67。结论：MELD评分系统与CTP评分均能准确评估肝硬化患者肝脏储备功能，MELD评分较CTP评分具有更高的精确性和准确性。
Abstract
Objective: To determine the assessment performance of model for end-stage liver disease(MELD) and Child-Tureotte-Pugh(CTP) score in comparison with liver volume in liver reserve function of hepatitis B-related cirrhosis. Methods: Fifty-two patients who were diagnosed with liver cirrhosis based on the clinical findings, including liver pathology, radiological, and the results of laboratory examinations were included in this study. The total liver volume was measured according to abdominal contrast enhancement by 256-slice iCT, and then, the standardization of the total liver volume(SLV) was obtained. According to the laboratory and clinical data, we calculated the MELD score and Child score respectively, and a scatter plot was got between body surface area and liver volume. The MELD and CTP score correlation was correlated with the SLV. Results: The total liver volume was (989.4±293.7) cm3, and the SLV was (532.3±143.2) cm3/m2. The MELD and CTP score was 14.37±6.19, 8.71±2.80, respectively. Negative linear correlations were observed between SLV and the MELD, CTP score(r=-0.82, r=-0.685, respectively; all P<0.05). The coefficient of determination was 0.47, 0.67 respectively. Conclusion: CTP score and MELD score system could accurately assess liver reserve function in patients with cirrhosis, MELD score has greater precision and accuracy than CTP score.
关键词
肝硬化 /
体层摄影术 /
螺旋计算机
Key words
Liver cirrhosis /
Tomography, spiral computed
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