目的：应用左室心腔造影技术提高心肌与心腔之间的对比度，诊断并且评价心尖部肥厚型心肌病。方法：选取临床上怀疑心尖部肥厚型心肌病患者21例，患者心电图均有异常改变，排除既往高血压病史、主动脉瓣疾病等可能引起继发性心肌肥厚的疾病，并且二维超声心动图检查无其他节段心肌异常增厚改变，仅心尖部受近场伪影和声窗限制、气体干扰或因患者肥胖等原因而导致二维超声图像显示不清。21例患者行左室心腔造影检查后，对图像进行整理分析。20例无心脏疾病患者作为正常对照组。结果：21例患者造影过程中无任何不适表现，心腔超声造影成功显示心尖部20例（95.2%），其中2例患者心尖部心肌未见明显增厚，18例患者心尖部心肌增厚明显，厚约14~17 mm，心尖部心肌节段呈现放射状分布的粗大增多的小梁及深陷其间被造影剂充填的隐窝。造影后能清晰观察到收缩末期左心室腔心尖部明显狭窄，甚至完全闭塞。1例（4.8%）患者因左室射血分数（EF）低，造影剂未能到达心尖部，未能成功显影。心尖部肥厚型心肌病患者EF与对照组比较无统计学差异，但左心室舒张末容积（EDV）和收缩末容积（ESV）均较对照组减小。结论：左室心腔造影技术可以提高心脏超声图像的清晰度，准确地测量心尖部心肌的厚度，判断心腔大小的改变，提高心尖部肥厚型心肌病的诊断符合率。

Objective: To improve the contrast of myocardium and cardiac cavity by left ventricular opacification, and to diagnose and evaluate apical hypertrophic cardiomyopathy. Methods: We selected 21 patients clinically suspected of apical hypertrophic cardiomyopathy with abnormal change of electrocardiogram, excluded diseases such as high blood pressure, aortic valve disease and so on which may cause secondary myocardial hypertrophy. There was no other segmental myocardial abnormal thickening of the change in the two-dimensional echocardiography imaging, only the apex of heart was not clear by image display forthe near field artifacts and acoustic window limit, gas interference or by reason of patients with obesity caused. Twenty-one cases of patients undergoed left ventricular opacification, organized and analysis the images. Twenty patients without heart disease as a normal control group. Results: Twenty-one cases of patients with imaging process did not feel any discomfort. The ultrasound imaging of left ventricular opacification success showed apex of 20 cases(95.2%). Including 2 cases of apex of myocardial no obvious thickening, 18 patients with apical myocardial thickening, thickness of about 14~17 mm. The apical apical segment of the myocardium with a radial distribution of a large number of trabeculae and deep recess filled with contrast media. After left ventricular opacification, we can clearly observe that the left ventricular apex of the left ventricle is obviously narrowed or even completely occluded. One case(4.8%) patients with left ventricular ejection fraction, contrast agent fails to reach the apex, failed to development. There was no significant difference between EF and control group in apical hypertrophic cardiomyopathy, but EDV and ESV were significantly lower than those in control group. Conclusion: Left ventricular opacification can increase the diagnostic accuracy of apical hypertrophic cardiomyopathy by improving the clarity of the cardiac ultrasound image, measuring the thickness of the apical myocardium accurately, and judging the change of the cardiac cavity size.