目的：探讨间质性肺疾病（ILD）患者肺超声评分与肺功能的相关性。方法：43例临床资料完整的ILD患者，1周内均行HRCT、肺超声、肺功能检查，按照肺超声图像表现（胸膜厚度、胸膜表面情况、胸膜下结节、B线条数最多的一个切面所显示的B线条数）进行肺超声评分，与肺功能指标（第1 s用力呼气容积（FEV1）、用力肺活量（FVC）、肺总量（TLC）、残气量（RV）、肺一氧化碳弥散量（DLCO）、弥散系数（DLCO/VA））、胸部HRCT图像表现进行相关分析。结果：肺超声评分总分、胸膜评分、B线评分与部分肺功能指标（FVC、FEV1、DLCO、DLCO/VA）呈负相关，其中DLCO与肺超声评分总分（r=-0.570，P＜0.000），胸膜评分（r=-0.563，P＜0.000）、以及B线评分（r=-0.594，P＜0.000）相关关系最显著，肺超声评分在HRCT间质病变早期和晚期图像间差异有统计学意义（P＜0.05）。结论：ILD的肺超声评分与肺功能的主要指标呈负相关，肺超声评分在HRCT间质病变早期和晚期图像间差异有统计学意义，肺超声评分可以在一定程度上反映肺部受累的严重程度。
Abstract
Objective: To discuss the relationship between pulmonary ultrasound score and function of lung in patients with interstitial lung disease(ILD). Methods: Forty-three patients with ILD who had complete clinical data underwent HRCT, pulmonary ultrasound and lung function within a week. They were graded by pulmonary ultrasound according to the lung sonography image characteristics(pleural thickness, pleural surface, subpleural nodules, B lines in a section that shows the maximum number). The correlation analysis of pulmonary ultrasound score, index of lung function(FEV1, FVC, TLC, RV, DLCO, DLCO/VA) and chest HRCT image was performed. Results: A negative correlation was found between total score of lung ultrasound, pleural score, B line score and some index of lung function(FVC, FEV1, DLCO, DLCO/VA), and there was the most significant relationship between DLCO and total score of lung ultrasound(r=-0.570, P<0.000), pleural score(r=-0.563, P<0.000), B line score(r=-0.594, P<0.000). The difference between early and late images of ultrasound score in HRCT interstitial lung disease was statistically significant(P<0.05). Conclusion: A negative correlation is found between lung ultrasound score and the main indicators of lung function. The difference between early and late images of ultrasound score in HRCT interstitial lung disease is statistically significant(P<0.05). Pulmonary ultrasound score can reflect the severity of lung to some extent.
关键词
肺疾病 /
间质性 /
超声检查 /
多普勒 /
彩色 /
体层摄影术 /
螺旋计算机
Key words
Lung diseases, interstitial /
Ultrasonography, Doppler, color /
Tomography, spiral computed
中图分类号：
Ｒ563.13
Ｒ445.1
Ｒ814.42
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