目的：探讨早期宫颈癌18F-FDG PET/CT显像中盆腔高摄取淋巴结性质的鉴别。方法：回顾性分析53例具有18F-FDG高摄取原发灶及盆腔淋巴结的早期宫颈癌患者的资料，以手术病理为参照标准，评价转移与非转移淋巴结的短径、最大标准摄取值（SUVmax）、平均标准摄取值（SUVmean）、肿瘤代谢体积（MTV）、糖酵解总量（TLG）是否存在统计学差异，选取有统计学差异的参数进行ROC曲线分析，并对各曲线进行两两比较。结果：共有76枚18F-FDG高摄取淋巴结纳入研究。转移组与非转移组之间短径、SUVmax、SUVmean、MTV、TLG比较均具有统计学差异（P均<0.05），相应曲线下面积分别为0.76、0.87、0.86、0.67、0.79，敏感度分别为60.61%、75.76%、72.73%、54.55%、66.67%，特异度分别为86.05%、88.37%、88.37%、76.74%、81.40%；SUVmax与短径、MTV、TLG之间，SUVmean与MTV之间、MTV与TLG之间比较ROC曲线具有统计学差异（P均<0.05）。结论：18F-FDG PET/CT对早期宫颈癌盆腔内高摄取淋巴结性质的鉴别具有一定价值，SUVmax、SUVmean是相对较好的指标。
Abstract
Objective: To differentiate the pelvic lymph nodes with high FDG uptake in early-stage cervical carcinoma using 18F-FDG PET/CT imaging. Methods: Fifty-three cases with FDG avid primary lesions and pelvic lymph nodes were retrospectively analyzed. Short axis, SUVmax, SUVmean, MTV and TLG of the lymph nodes were compared between the metastasis group and non-metastasis group. The diagnostic efficacies of statistically significant parameters were calculated and compared. Results: Seventy-six 18F-FDG high-uptake lymph nodes were included in the following analysis. All the 5 parameters mentioned above were statistically different(P<0.05). The AUCs of short axis, SUVmax, SUVmean, MTV and TLG were 0.76, 0.87, 0.86, 0.67, 0.79, while their sensitivity and specificity were 60.61%, 75.76%, 72.73%, 54.55%, 66.67%, and 86.05%, 88.37%,88.37%, 76.74%, 81.40% respectively. Statistical difference existed between ROCs of SUVmax and short axis, MTV, as well as TLG, while the difference was also confirmed between SUVmean and MTV, MTV and TLG(P<0.05). Conclusion: 18F-FDG PET/CT is useful in differentiating pelvic lymph nodes with high FDG uptake in early-stage cervical carcinoma. SUVmax and SUVmean can be promising parameters.PET/CT
关键词
宫颈肿瘤 /
氟脱氧葡萄糖F18 /
正电子发射断层显像术
Key words
Cervix neoplasms /
Fluorodeoxyglucose F18 /
Positron-emission tomography
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