目的：探讨超声测量肝前脂肪厚度对诊断代谢综合征的价值。方法：对496例内分泌科随访的社区人群按代谢综合征相关各组分疾病分组，用超声测量肝前脂肪厚度、腹内脂肪厚度，分析肝前脂肪厚度、腹内脂肪厚度与腰围之间的相关性，并用受试者特征（ROC）曲线分析肝前脂肪厚度诊断代谢综合征的最佳临界值。结果：肝前脂肪厚度、腹内脂肪厚度均与腰围呈正相关（P<0.01）；肝前脂肪厚度与腰围的相关系数大于腹内脂肪厚度与腰围的相关系数。男性肝前脂肪厚度诊断代谢综合征的最佳临界值为1.30 cm，敏感度为0.70，特异度为0.81，ROC曲线下面积为0.82（P<0.01）；女性肝前脂肪厚度诊断代谢综合征的最佳临界值为1.27 cm，敏感度为 0.88，特异度为0.74，ROC曲线下面积为0.87（P<0.01）。结论：超声测量肝前脂肪厚度可替代腰围，作为评价腹内脂肪堆积程度的准确诊断代谢综合征的指标之一。
Abstract
Objective: To evaluate the value of ultrasonographic measurement of prehepatic fat thickness in the diagnosis of metabolic syndrome. Methods: Four hundred and ninety-six cases of community endocrinology follow-up were divided into groups according to metabolic syndrome. Ultrasound was used to measure the prehepatic fat thickness and the visceral fat thickness. The correlation between prehepatic fat thickness, intra-abdominal fat thickness and waist circumference was analyzed. ROC curve was used to analyze the optimal critical value of prehepatic fat thickness for the diagnosis of metabolic syndrome. Results: There was a positive correlation between the prehepatic fat thickness, the visceral fat thickness and the waist circumference(P<0.01). The correlation coefficient between the prehepatic fat thickness and waist circumference is more than that of the visceral fat thickness and waist circumference. The optimal critical value of the prehepatic fat thickness of male in diagnosing metabolic syndrome was 1.30 cm, the sensitivity and specificity was 0.70 and 0.81, the area under the curve was 0.82(P<0.01). The optimal critical value of the prehepatic fat thickness of female in diagnosing metabolic syndrome was 1.27 cm, the sensitivity and specificity was 0.88 and 0.74, the area under the curve was 0.87(P<0.01). Conclusion: Instead of the waist circumference, ultrasound measurement of prehepatic fat thickness is one of an accurate indicator metabolic syndrome of the degree of accumulation of intra-abdominal fat.
关键词
代谢综合征X /
超声检查
Key words
Metabolic syndrome X /
Ultrasonography
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基金
“十二五”国家科技计划课题（NO.2012BAI02B00）。
