目的：应用极速成像技术（Ultrafast imaging，UltraFastTM）评价代谢综合征（MS）患者颈动脉弹性早期改变。方法：选取MS组48例，代谢异常组55例，正常组50例。检测双侧颈总动脉内-中膜厚度（IMT），UltraFastTM检测脉搏波传导速度（PWV），包括收缩期起始时PWV（PWV-BS）及收缩期结束时PWV（PWV-ES）。结果：代谢异常组与正常组间IMT、PWV-BS及PWV-ES无差异（P＞0.05），而MS组IMT、PWV-BS、PWV-ES均高于正常组及代谢异常组（P＜0.05）。结论：MS患者颈动脉弹性减低，UltraFastTM通过测量颈动脉PWV可成为一种早期快速评估MS患者颈动脉硬化的新方法。
Abstract
Objective: To assess the application value of Ultrafast imaging for the early evaluation of carotid functional change in patients with metabolic syndrome. Methods: There were 48 metabolic syndrome cases(metabolic syndrome group), 55 metabolic abnormality cases(metabolic abnormality group) and 50 healthy cases(control group). The inter-media thickness(IMT) and pulse wave velocity(PWV), including the PWV at the beginning of the systole(PWV-BS) and the PWV at the ending of the systole(PWV-ES), were evaluated. Results: IMT, PWV-BS and PWV-ES in the metabolic syndrome group were higher than those in the control group and metabolic abnormality group(P<0.05). Those were no difference between the metabolic abnormality group and control group(P>0.05). Conclusion: The carotid artery elasticity in patients with metabolic syndrome decreased. The UltraFast technique is expected to be a new method to early rapidly evaluate the carotid atherosclerosis in patients with metabolic syndrome.
关键词
代谢综合征X /
颈动脉疾病 /
超声检查 /
多普勒 /
彩色
Key words
Metabolic syndrome X /
Carotid artery diseases /
Ultrasonography, Doppler, color
中图分类号：
Ｒ543.4
Ｒ587
Ｒ445.1
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
参考文献
[1]Timóteo AT, Mota Carmo M, Cruz Ferreira R. Does metabolic syndrome predict significant angiographic coronary artery disase?[J]. Revista Potuguesa De Cardiologia, 2012, 31(12): 769-778.
[2]Dangas GD, Serruys PW, Kereiakes DJ, et al. Meta-analysis of everolimus eluting versus paclitaxel eluting stents in coronary artery disease: Final 3 year results of SPIRIT clinical trials program(clinical evaluation of the xience V everolimus cluting coronary stent system in the treatment of patients with de novo native coronary artery lesions[J]. JACC Cardiovasc Interv, 2013, 6(9): 917-922.
[3]Salles S, Chee AJ, Garcia D, et al． 2-D arterial wall motion imaging using ultrafast ultrasound and transverse oscillations[J]． IEEE Trans Ultrason Ferroelectr Freq Control, 2015, 62(6): 1047-1058．
[4]王晓玉，刘永铭，周新人，等. 2型糖尿病患者脉搏波速度的变化及其影响因素[J]. 中国糖尿病杂志，2010，18（10）：767-769.
[5]Alberli KG, Eckel RH, Grundy SM, et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation: International Atheroselerosis Society; and International Association for the Study of Obesity[J]. Circulation, 2009, 120(16): 1640-1645．
[6]张红，姜珏，周琦. 极速脉搏波技术定量评价健康成人颈动脉弹性的研究[J]. 临床超声医学杂志，2015，17（7）：457-460.
[7]Mottillo S, Filion KB, Genest J, et al. The metabolic syndrome and cardiovascular risk: a systematic review and meta-analysis[J]. JACC, 2010, 56(14): 1113-1132．
[8]Sandeep S, Gokulakrishnan K, Deepa M, et al. Insulin resistance is associated with increased cardiovascular risk in Asian Indians with normal glucose tolerance—the Chennai Urban Rural Epidemiology Study(Cures-66)[J]. J Assoc Physicians India, 2011, 59: 480-484.
[9]Watson NL, Sutton-Tyrrell K, Youk AO, et al． Anerial stiffness and gait speed in older adults with and without peripheral arterial disease[J]． Am J Hypertens, 2011, 24(1): 90-95．
[10]Hodis S, Zamir M. Pulse wave velocity as a diagnostic index: the pitfalls of tethering versus stiffening of the arterial wall[J]. J Biomech, 2011, 44(7): 1367-1373.
[11]邱兰燕，钱林学，刘冬，等. 极速成像技术检测的脉搏波传导速度与颈动脉硬化相关性的研究[J]. 中华超声影像学杂志，2014，23（3）：203-205.
基金
代谢综合征的早期识别和干预技术研究（2009BAI80B00）；辽宁省高等学校重大科技平台基金（16010）。
