目的：应用实时剪切波弹性成像（SWE）技术检测成年女性单纯性增生性病变乳腺各解剖层的弹性模量值，探讨不同月经周期以及年龄对增生性病变乳腺腺体组织硬度的影响。方法：选取2015年1—11月到我院健康体检的成年女性乳腺增生性病变60例，按年龄段分为3组，每组20例。应用SWE检测成年女性单纯性增生性病变乳腺不同月经周期、不同象限各解剖层的弹性模量值。结果：不同月经周期，增生性病变乳腺腺体弹性模量值变化无统计学意义（P>0.05）；同一月经周期，增生性病变乳腺腺体弹性模量值（平均值、最大值）随年龄的增加而增加（P＜0.05）。结论：SWE作为一种无创的超声检查方法能较准确、客观的评价年龄及月经周期与增生性病变的乳腺腺体组织硬度的关系。

Objective: To investigate the effect of different menstrual cycle and age on the hardness of mammary gland tissue of proliferative lesions, the elastic modulus values of different anatomical layers of adult female simple proliferative lesions were detected by real-time shear wave elasticity imaging(SWE). Methods: Sixty adult patients with mammary gland hyperplasia were enrolled in our hospital from January to November in 2015. The patients were divided into three groups according to their age. SWE was used to detect the elastic modulus of different menstrual cycles and different anatomical layers in adult female patients with simple proliferative lesions. Results: There was no significant difference in elastic modulus of mammary glands between different menstrual cycles and proliferative lesions(P>0.05). The elastic modulus values(mean value and maximum value) of mammary glands in the same menstrual cycle and proliferative lesions increased with age(P<0.05).