视神经脊髓炎患者背侧注意网络的静息态功能磁共振研究

郭  溪; 张  雪; 张宁男楠; 于春水

doi:10.12117/jccmi.2018.08.003

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中国临床医学影像杂志 ›› 2018, Vol. 29 ›› Issue (8) : 539-542. DOI: 10.12117/jccmi.2018.08.003

中枢神经影像学

视神经脊髓炎患者背侧注意网络的静息态功能磁共振研究

郭溪，张雪，张宁男楠，于春水

作者信息 +

Resting-state functional magnetic resonance imaging study of dorsal attention network in neuromyelitis optica

GUO Xi, ZHANG Xue, ZHANG Ning-nan-nan, YU Chun-shui

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文章历史 +

摘要

目的：本文旨在探索视神经脊髓炎（NMO）患者注意功能的缺陷，分析静息状态下NMO患者背侧注意网络（DAN）内功能连接强度（FCS）的变化。方法：本研究共纳入43例NMO患者及性别、年龄及教育程度匹配的44例正常被试，使用符号-数字模式测验（SDMT）对受试者进行注意功能的评价并采集静息态功能磁共振数据。运用种子点及联合分析的方法构建DAN，并进行DAN内的FCS分析，采用双样本t检验统计比较两组差异并对结果进行基于体素水平假阳性率（FDR）的多重比较校正（P<0.05）。结果：与正常被试相比，NMO患者SDMT评分显著降低，提示NMO患者存在注意缺陷。同时，NMO患者DAN内存在FCS的变化，包括双侧中央后回FCS的减低、左侧顶上小叶及左侧额上回FCS的升高。结论：本文揭示了NMO患者静息态DAN内局部脑区FCS的变化，这可能是NMO患者注意缺陷的神经生理基础之一。

Abstract

Objective: To explore attention deficiency and resting-state functional connectivity strength(FCS) changes in the dorsal attention network(DAN) of neuromyelitis optica(NMO) patients. Methods: A total of 43 NMO patients and 44 age-, sex- and education-matched healthy controls were enrolled in our study. Attentional function was assessed by the symbol-digit modalities test(SDMT) and resting-state functional magnetic resonance imaging(fMRI) data were also acquired for each subject. Seed-based and conjunction analyses were used to extract the DAN. FCS maps of DAN were obtained for each subject and were then compared between the two groups using a two-sample t test. Multiple comparisons were corrected by a voxel-wise false discovery rate(FDR) method with a threshold of P<0.05. Results: NMO patients performed significantly worse on SDMT relative to healthy controls, suggesting the attention disturbance in NMO. FCS changes were also found in DAN of NMO, including decrease in bilateral postcentral gyrus, and an increase in the left superior parietal lobule and the left superior frontal gyrus. Conclusion: Altered FCS was found in DAN of NMO patients, which may be part of the neural foundation of attention deficiency in NMO.

导出引用

郭溪，张雪，张宁男楠，于春水. 视神经脊髓炎患者背侧注意网络的静息态功能磁共振研究[J]. 中国临床医学影像杂志. 2018, 29(8): 539-542 https://doi.org/10.12117/jccmi.2018.08.003

GUO Xi, ZHANG Xue, ZHANG Ning-nan-nan, YU Chun-shui. Resting-state functional magnetic resonance imaging study of dorsal attention network in neuromyelitis optica[J]. Journal of China Clinic Medical Imaging. 2018, 29(8): 539-542 https://doi.org/10.12117/jccmi.2018.08.003

中图分类号： Ｒ744.52 Ｒ445.2

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