目的：探讨不同分子亚型乳腺癌超声造影特征及定量参数差异性。方法：对94例经术后病理证实的乳腺癌患者进行术前超声造影检查，依据术后免疫组化结果进行分子亚型分型，对不同分子亚型乳腺癌患者的超声造影特征及定量参数进行分析。结果：分子亚型中管腔上皮型与非管腔上皮型在增强模式及增强后范围是否扩大两者间比较差异具有统计学意义（P<0.05），管腔上皮型以快进慢退多见，而非管腔上皮型以快进快退多见，非管腔上皮型增强后范围扩大多见；增强模式中Luminal A型以快进慢退多见，Her-2过表达型及过基底样型以快进快退多见；过基底样型的增强幅度以高增强为主，而Luminal B型及Her-2过表达型虽然也以高增强为主，但同时可见其他增强幅度；Her-2过表达型增强后边界不清更多见；Luminal B型及Her-2过表达型以充盈缺损更为常见；过基底样型增强后范围扩大更为多见；定量参数指标中Luminal B型上升支斜率高于Luminal A型，Her-2过表达型上升支斜率高于Luminal A型，曲线下面积大于Luminal A型，过基底样型上升支斜率高于Luminal A型（P均<0.05）。结论：不同分子亚型乳腺癌超声造影特征及定量参数之间存在差异，能够对术前乳腺癌分子亚型进行预测，为乳腺癌新辅助化疗及个体化治疗提供影像学参考依据。
Abstract
Objective: To investigate the difference of ultrasonographic features and quantitative parameters of different molecular subtypes of breast cancer. Methods: Preoperative ultrasonography was performed in 94 patients with breast cancer confirmed by pathology, and the characteristics and quantitative parameters of ultrasonography in different patients with breast cancer were analyzed. Results: There was a statistically significant difference in the enhancement pattern and the expansion of the enhancement range between the luminal epithelia and non-luminal epithelia(P<0.05), which the luminal epithelia mainly showed fast forward and slow backward and non-luminal epithelia mainly showed fast forward and backward and expansion of scope. In the enhanced mode, fast forward and slow backward were more common in Luminal A, and fast forward and fast backward were more common in Her-2 over-expression and basal-like. High enhancement was dominant in basal-like, high enhancement was also found in Luminal B and Her-2 over-expression, but other enhancement levels were also found. The unclear boundary was more common in Her-2 over-expression. The filling defects were more common in Luminal B and Her-2 over-expression. Expansion of scope was more common in basal-like. In the quantitative parameter index, the ascending branch slope of Luminal B was higher than that of Luminal A, the ascending branch slope of Her-2 over-expression was higher than that of Luminal A, the area under the curve was larger than that of Luminal A, and the ascending branch slope of basal-like was higher than that of Lumin A(P<0.05). Conclusion: There are differences between the characteristics and quantitative parameters of different molecular subtypes of breast cancer, which can be used to provide imaging reference for breast cancer chemotherapy and individual therapy.
关键词
乳腺肿瘤 /
超声检查
Key words
Breast neoplasms /
Ultrasonography
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