目的：探讨3.0T MR弹性成像（MRE）评价非酒精性脂肪肝（Non-alcoholic fatty liver disease，NAFLD）患者肝纤维化的作用。方法：采用3.0T MRE分析20例健康志愿者（正常组）及57例肝脏活检诊断患有NAFLD的患者（病变组）的肝脏弹性值。采用受试者工作特征曲线（ROC）评价MRE鉴别NAFLD的诊断效能。结果：正常组及病变组的肝脏弹性值分别为（1.97±0.43） kPa及（4.05±1.70） kPa，二者间差异有统计学意义（t=-8.518，P<0.001）；MRE诊断NAFLD≥F1、≥F2、≥F3及F4的ROC曲线下面积（AUC）均高于NAFLD纤维化分数（NFS），分别为0.92（NFS：0.74）、0.94（NFS：0.81）、0.95（NFS：0.85）、0.99（NFS：0.91）（AUC值比较P均<0.05）。结论：MRE是一种可靠的评价NAFLD患者纤维化分期的方法，优于血清学指标。
Abstract
Objective: To investigate the effect of 3.0T magnetic resonance elastography(MRE) on the evaluation of non-alcoholic fatty liver disease(NAFLD) patients and prediction the liver fibrosis. Methods: The preoperative liver stiffness of 20 healthy volunteers(normal group) and 57 patients(pathological group) diagnosed with NAFLD by liver biopsy were analyzed by 3.0T MRE. Receiver operating characteristic curve(ROC) was used to evaluate the diagnostic efficacy of MRE in the staging liver fibrosis. Results: The shear stiffness of the normal group and the pathological group were (1.97±0.43) kPa and (4.05±1.70) kPa, with statistical significance(t=-8.518, P<0.001). The AUC of MRE for diagnosising ≥F1, ≥F2, ≥F3 and F4 liver fibrosis in NAFLD patients was 0.92, 0.94, 0.95 and 0.99, respectively, all of which were higher than that of NFS(0.74, 0.81, 0.85 and 0.91, respectively). Conclusion: MRE is a reliable tool for the evaluation of different stages of fibrosis in NAFLD patients.
关键词
脂肪肝 /
肝炎 /
磁共振成像
Key words
Fatty liver /
Hepatitis /
Magnetic resonance imaging
中图分类号：
Ｒ575.5
Ｒ575.1
Ｒ445.2
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基金
国家自然科学基金面上项目（81771802，81771893）。
